ID   HEPC_ONCMY              Reviewed;          61 AA.
AC   Q9DFD6;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Hepcidin;
DE   Flags: Precursor; Fragment;
GN   Name=hamp;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11164886; DOI=10.1016/s0145-305x(00)00057-4;
RA   Bayne C.J., Gerwick L., Fujiki K., Nakao M., Yano T.;
RT   "Immune-relevant (including acute phase) genes identified in the livers of
RT   rainbow trout, Oncorhynchus mykiss, by means of suppression subtractive
RT   hybridization.";
RL   Dev. Comp. Immunol. 25:205-217(2001).
CC   -!- FUNCTION: Seems to act as a signaling molecule involved in the
CC       maintenance of iron homeostasis. Seems to be required in conjunction
CC       with HFE to regulate both intestinal iron absorption and iron storage
CC       in macrophages. May also have antimicrobial activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the hepcidin family. {ECO:0000305}.
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DR   EMBL; AF281354; AAG30029.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:AgBase.
DR   InterPro; IPR010500; Hepcidin.
DR   Pfam; PF06446; Hepcidin; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Secreted.
FT   PROPEP          <1..34
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000013393"
FT   PEPTIDE         37..61
FT                   /note="Hepcidin"
FT                   /id="PRO_0000013394"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        43..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..55
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..58
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   61 AA;  6946 MW;  B8C2B7917E98454F CRC64;
     LQVLTEEVGS IDSPVGEHQQ PGGESMRLPE HFRFKRXSHL SLCRWCCNCC HNKGXGFCCK
     F