HEPC_PIG
ID HEPC_PIG Reviewed; 82 AA.
AC Q8MJ80;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Hepcidin;
DE Flags: Precursor;
GN Name=HAMP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sang Y., Ross C.R., Blecha F.;
RT "Cloning and characterization of porcine liver-expressed antimicrobial
RT peptides, Hepcidin (pHAMP) and LEAP2.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Liver-produced hormone that constitutes the main circulating
CC regulator of iron absorption and distribution across tissues. Acts by
CC promoting endocytosis and degradation of ferroportin/SLC40A1, leading
CC to the retention of iron in iron-exporting cells and decreased flow of
CC iron into plasma. Controls the major flows of iron into plasma:
CC absorption of dietary iron in the intestine, recycling of iron by
CC macrophages, which phagocytose old erythrocytes and other cells, and
CC mobilization of stored iron from hepatocytes.
CC {ECO:0000250|UniProtKB:P81172}.
CC -!- FUNCTION: Has strong antimicrobial activity against E.coli ML35P
CC N.cinerea and weaker against S.epidermidis, S.aureus and group b
CC streptococcus bacteria. Active against the fungus C.albicans. No
CC activity against P.aeruginosa. {ECO:0000250|UniProtKB:P81172}.
CC -!- SUBUNIT: Interacts with SLC40A1; this interaction promotes SLC40A1
CC rapid ubiquitination. {ECO:0000250|UniProtKB:P81172}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the hepcidin family. {ECO:0000305}.
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DR EMBL; AF516143; AAM77745.1; -; mRNA.
DR RefSeq; NP_999282.1; NM_214117.1.
DR AlphaFoldDB; Q8MJ80; -.
DR SMR; Q8MJ80; -.
DR STRING; 9823.ENSSSCP00000003108; -.
DR PaxDb; Q8MJ80; -.
DR Ensembl; ENSSSCT00000040953; ENSSSCP00000042081; ENSSSCG00000035436.
DR Ensembl; ENSSSCT00040086541; ENSSSCP00040037957; ENSSSCG00040063437.
DR Ensembl; ENSSSCT00040096614; ENSSSCP00040042929; ENSSSCG00040070425.
DR Ensembl; ENSSSCT00070020080; ENSSSCP00070016695; ENSSSCG00070010319.
DR GeneID; 397207; -.
DR KEGG; ssc:397207; -.
DR CTD; 57817; -.
DR VGNC; VGNC:88776; HAMP.
DR eggNOG; ENOG502T0FU; Eukaryota.
DR GeneTree; ENSGT00390000003154; -.
DR HOGENOM; CLU_2557737_0_0_1; -.
DR InParanoid; Q8MJ80; -.
DR OMA; PICLFCC; -.
DR OrthoDB; 1623838at2759; -.
DR TreeFam; TF330932; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Proteomes; UP000314985; Chromosome 6.
DR Bgee; ENSSSCG00000035436; Expressed in liver and 11 other tissues.
DR Genevisible; Q8MJ80; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0034755; P:iron ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0002262; P:myeloid cell homeostasis; IEA:Ensembl.
DR GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:1904479; P:negative regulation of intestinal absorption; IEA:Ensembl.
DR GO; GO:0034760; P:negative regulation of iron ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0010039; P:response to iron ion; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR InterPro; IPR010500; Hepcidin.
DR PANTHER; PTHR16877; PTHR16877; 1.
DR Pfam; PF06446; Hepcidin; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..53
FT /evidence="ECO:0000255"
FT /id="PRO_0000013383"
FT PEPTIDE 58..82
FT /note="Hepcidin"
FT /id="PRO_0000013384"
FT DISULFID 64..80
FT /evidence="ECO:0000250"
FT DISULFID 67..70
FT /evidence="ECO:0000250"
FT DISULFID 68..76
FT /evidence="ECO:0000250"
FT DISULFID 71..79
FT /evidence="ECO:0000250"
SQ SEQUENCE 82 AA; 8771 MW; 78F23A1C9D01E4EA CRC64;
MALSVQIRAA CLLLLLLVSL TAGSVLPSQT RQLTDLRTQD TAGATAGLTP VAQRLRRDTH
FPICIFCCGC CRKAICGMCC KT
