ID   HEPC_PONAB              Reviewed;          84 AA.
AC   Q5NVR8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Hepcidin;
DE   Flags: Precursor;
GN   Name=HAMP; Synonyms=HEPC;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Liver-produced hormone that constitutes the main circulating
CC       regulator of iron absorption and distribution across tissues. Acts by
CC       promoting endocytosis and degradation of ferroportin/SLC40A1, leading
CC       to the retention of iron in iron-exporting cells and decreased flow of
CC       iron into plasma. Controls the major flows of iron into plasma:
CC       absorption of dietary iron in the intestine, recycling of iron by
CC       macrophages, which phagocytose old erythrocytes and other cells, and
CC       mobilization of stored iron from hepatocytes.
CC       {ECO:0000250|UniProtKB:P81172}.
CC   -!- FUNCTION: Has strong antimicrobial activity against E.coli ML35P
CC       N.cinerea and weaker against S.epidermidis, S.aureus and group b
CC       streptococcus bacteria. Active against the fungus C.albicans. No
CC       activity against P.aeruginosa. {ECO:0000250|UniProtKB:P81172}.
CC   -!- SUBUNIT: Interacts with SLC40A1; this interaction promotes SLC40A1
CC       rapid ubiquitination. {ECO:0000250|UniProtKB:P81172}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hepcidin family. {ECO:0000305}.
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DR   EMBL; CR925937; CAI29595.1; -; mRNA.
DR   RefSeq; NP_001127676.1; NM_001134204.1.
DR   AlphaFoldDB; Q5NVR8; -.
DR   SMR; Q5NVR8; -.
DR   STRING; 9601.ENSPPYP00000011035; -.
DR   PRIDE; Q5NVR8; -.
DR   GeneID; 100174758; -.
DR   KEGG; pon:100174758; -.
DR   CTD; 57817; -.
DR   eggNOG; ENOG502T0FU; Eukaryota.
DR   InParanoid; Q5NVR8; -.
DR   OrthoDB; 1623838at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR010500; Hepcidin.
DR   PANTHER; PTHR16877; PTHR16877; 1.
DR   Pfam; PF06446; Hepcidin; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..54
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000223274"
FT   PEPTIDE         60..84
FT                   /note="Hepcidin"
FT                   /id="PRO_0000045323"
FT   DISULFID        69..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..78
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   84 AA;  9374 MW;  B16D2CBBC9B0E83D CRC64;
     MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARAGWT PMLQRRRRRD
     THFPIYIFCC GCCHRSKCGM CCKT