HEPC_RAT
ID HEPC_RAT Reviewed; 84 AA.
AC Q99MH3;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Hepcidin;
DE Flags: Precursor;
GN Name=Hamp; Synonyms=Hepc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=11113132; DOI=10.1074/jbc.m008923200;
RA Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P.,
RA Loreal O.;
RT "A new mouse liver-specific gene, encoding a protein homologous to human
RT antimicrobial peptide hepcidin, is overexpressed during iron overload.";
RL J. Biol. Chem. 276:7811-7819(2001).
CC -!- FUNCTION: Liver-produced hormone that constitutes the main circulating
CC regulator of iron absorption and distribution across tissues. Acts by
CC promoting endocytosis and degradation of ferroportin/SLC40A1, leading
CC to the retention of iron in iron-exporting cells and decreased flow of
CC iron into plasma. Controls the major flows of iron into plasma:
CC absorption of dietary iron in the intestine, recycling of iron by
CC macrophages, which phagocytose old erythrocytes and other cells, and
CC mobilization of stored iron from hepatocytes.
CC {ECO:0000250|UniProtKB:P81172}.
CC -!- FUNCTION: Has strong antimicrobial activity against E.coli ML35P
CC N.cinerea and weaker against S.epidermidis, S.aureus and group b
CC streptococcus bacteria. Active against the fungus C.albicans. No
CC activity against P.aeruginosa. {ECO:0000250|UniProtKB:P81172}.
CC -!- SUBUNIT: Interacts with SLC40A1; this interaction promotes SLC40A1
CC rapid ubiquitination. {ECO:0000250|UniProtKB:P81172}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the hepcidin family. {ECO:0000305}.
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DR EMBL; AF344185; AAK12966.1; -; mRNA.
DR RefSeq; NP_445921.1; NM_053469.1.
DR AlphaFoldDB; Q99MH3; -.
DR SMR; Q99MH3; -.
DR STRING; 10116.ENSRNOP00000028545; -.
DR PhosphoSitePlus; Q99MH3; -.
DR PaxDb; Q99MH3; -.
DR GeneID; 84604; -.
DR KEGG; rno:84604; -.
DR UCSC; RGD:70971; rat.
DR CTD; 57817; -.
DR RGD; 70971; Hamp.
DR VEuPathDB; HostDB:ENSRNOG00000021029; -.
DR eggNOG; ENOG502T0FU; Eukaryota.
DR HOGENOM; CLU_2557737_0_0_1; -.
DR InParanoid; Q99MH3; -.
DR OMA; PICLFCC; -.
DR OrthoDB; 1623838at2759; -.
DR PhylomeDB; Q99MH3; -.
DR TreeFam; TF330932; -.
DR PRO; PR:Q99MH3; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000021029; Expressed in liver and 19 other tissues.
DR Genevisible; Q99MH3; RN.
DR GO; GO:0045179; C:apical cortex; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0014704; C:intercalated disc; IDA:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005507; F:copper ion binding; ISO:RGD.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEP:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IDA:RGD.
DR GO; GO:1903413; P:cellular response to bile acid; IEP:RGD.
DR GO; GO:0071354; P:cellular response to interleukin-6; IEP:RGD.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR GO; GO:0071481; P:cellular response to X-ray; IEP:RGD.
DR GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR GO; GO:0050832; P:defense response to fungus; ISO:RGD.
DR GO; GO:0055072; P:iron ion homeostasis; ISO:RGD.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; ISO:RGD.
DR GO; GO:0002262; P:myeloid cell homeostasis; ISO:RGD.
DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:1904479; P:negative regulation of intestinal absorption; ISO:RGD.
DR GO; GO:0034760; P:negative regulation of iron ion transmembrane transport; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IMP:RGD.
DR GO; GO:0043032; P:positive regulation of macrophage activation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:RGD.
DR GO; GO:0036017; P:response to erythropoietin; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0010039; P:response to iron ion; ISO:RGD.
DR GO; GO:1990641; P:response to iron ion starvation; IEP:RGD.
DR GO; GO:0033189; P:response to vitamin A; IEP:RGD.
DR GO; GO:0010043; P:response to zinc ion; IEP:RGD.
DR InterPro; IPR010500; Hepcidin.
DR PANTHER; PTHR16877; PTHR16877; 1.
DR Pfam; PF06446; Hepcidin; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..54
FT /evidence="ECO:0000255"
FT /id="PRO_0000013385"
FT PEPTIDE 60..84
FT /note="Hepcidin"
FT /id="PRO_0000013386"
FT DISULFID 66..82
FT /evidence="ECO:0000250"
FT DISULFID 69..72
FT /evidence="ECO:0000250"
FT DISULFID 70..78
FT /evidence="ECO:0000250"
FT DISULFID 73..81
FT /evidence="ECO:0000250"
SQ SEQUENCE 84 AA; 9286 MW; 65E0D5FE4F44A0B0 CRC64;
MALSTRIQAA CLLLLLLASL SSGAYLRQQT RQTTALQPWH GAESKTDDSA LLMLKRRKRD
TNFPICLFCC KCCKNSSCGL CCIT
