HEPR_ASPOR
ID HEPR_ASPOR Reviewed; 235 AA.
AC Q2U0J5;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Transcription factor hepR {ECO:0000303|PubMed:30466366};
DE AltName: Full=Heptelidic acid biosynthesis cluster protein R {ECO:0000303|PubMed:30466366};
GN Name=hepR {ECO:0000303|PubMed:30466366}; ORFNames=AO090011000416;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=30466366; DOI=10.1080/09168451.2018.1549934;
RA Shinohara Y., Nishimura I., Koyama Y.;
RT "Identification of a gene cluster for biosynthesis of the sesquiterpene
RT antibiotic, heptelidic acid, in Aspergillus oryzae.";
RL Biosci. Biotechnol. Biochem. 83:1506-1513(2019).
CC -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC the biosynthesis of heptelidic acid (HA), a sesquiterpene lactone that
CC acts as an inhibitor of glyceraldehyde-3-phosphatedehydrogenase (GAPDH)
CC and a growth inhibitor of the salt-tolerant lactic acid bacteria in soy
CC sauce brewing (PubMed:30466366). Both hepR and hepS regulate the
CC transcription of the heptelidic acid cluster, but they are not involved
CC in mutual transcriptional regulation and act with different mechanisms
CC (PubMed:30466366). {ECO:0000269|PubMed:30466366}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:30466366}.
CC -!- DISRUPTION PHENOTYPE: Reduces markedly the expression of hepA and
CC abolishes the production of heptelidic acid.
CC {ECO:0000269|PubMed:30466366}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP007171; BAE64920.1; -; Genomic_DNA.
DR RefSeq; XP_001826053.1; XM_001826001.2.
DR AlphaFoldDB; Q2U0J5; -.
DR EnsemblFungi; BAE64920; BAE64920; AO090011000416.
DR GeneID; 5998156; -.
DR KEGG; aor:AO090011000416; -.
DR VEuPathDB; FungiDB:AO090011000416; -.
DR HOGENOM; CLU_1103381_0_0_1; -.
DR OMA; HYKQHFK; -.
DR Proteomes; UP000006564; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..235
FT /note="Transcription factor hepR"
FT /id="PRO_0000450835"
FT ZN_FING 175..205
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 14..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 26676 MW; 15839F267DAF55C1 CRC64;
MAETWMALPL FNRQNSPESS RDVLSMASPG LLPIDPSPEH DETNKFGPFD LLDNLPGELQ
LPADLNPARV GPTTHLPDLT DRADPEPRWM QISDLEVVGP GAVTCPFPGC KSTLRFTGSR
ELRRHYKQHF KRFFCRYPHC PQAGPGLQGP HPSTKRGFAT RKDRARHEAK HDPRIQCPCL
DERGERCSRM FSRLDNMRDH VRRIHNNSHY AGQETHGTAD AIPDIDIHHE IEARS