ID   HEPS1_GEOSE             Reviewed;         220 AA.
AC   P55784; P94455;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Heptaprenyl diphosphate synthase component 1;
DE            Short=HepPP synthase subunit 1;
DE            EC=2.5.1.30;
GN   Name=hepS; Synonyms=hepS-1;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10149 / DSM 6790 / CCM 5965 / CIP 105453 / JCM 11297 / NRS T15;
RX   PubMed=7629164; DOI=10.1074/jbc.270.31.18396;
RA   Koike-Takeshita A., Koyama T., Obata S., Ogura K.;
RT   "Molecular cloning and nucleotide sequences of the genes for two essential
RT   proteins constituting a novel enzyme system for heptaprenyl diphosphate
RT   synthesis.";
RL   J. Biol. Chem. 270:18396-18400(1995).
CC   -!- FUNCTION: Supplies heptaprenyl diphosphate, the precursor for the side
CC       chain of the isoprenoid quinone menaquinone-7 (MQ-7).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate =
CC         all-trans-heptaprenyl diphosphate + 4 diphosphate;
CC         Xref=Rhea:RHEA:27794, ChEBI:CHEBI:33019, ChEBI:CHEBI:58206,
CC         ChEBI:CHEBI:128769, ChEBI:CHEBI:175763; EC=2.5.1.30;
CC   -!- SUBUNIT: Heterodimer of component I and II.
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DR   EMBL; D49975; BAA08724.1; -; Genomic_DNA.
DR   AlphaFoldDB; P55784; -.
DR   SMR; P55784; -.
DR   BRENDA; 2.5.1.30; 623.
DR   GO; GO:0036422; F:heptaprenyl diphosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IDA:UniProtKB.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR009920; HEPPP_synth_su1.
DR   Pfam; PF07307; HEPPP_synt_1; 1.
PE   4: Predicted;
KW   Isoprene biosynthesis; Transferase.
FT   CHAIN           1..220
FT                   /note="Heptaprenyl diphosphate synthase component 1"
FT                   /id="PRO_0000124001"
SQ   SEQUENCE   220 AA;  24636 MW;  B536580918437D20 CRC64;
     MLDGASTAPS EAERCIIAMM LMQIALDTHD EVTDDGGDLR ARQLVVLAGD LYSGLYYELL
     ARSGETALIR SFAEAVRDIN EQKVRLYEKK VERIESLFAA VGTIESALLV KLADRMAAPQ
     WGQFAYSYLL MRRLLLEQEA FIRTGASVLF EQMAQIAFPR AKTLTKEQKR HLLRFCRRYI
     DGCREALFAA KLPVNGLLQL RVAELSGGFQ AIAKKTVEEG