ID   HEPS_ASPOR              Reviewed;         429 AA.
AC   Q2U0J4;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Transcription factor hepS {ECO:0000303|PubMed:30466366};
DE   AltName: Full=Heptelidic acid biosynthesis cluster protein S {ECO:0000303|PubMed:30466366};
GN   Name=hepS {ECO:0000303|PubMed:30466366}; ORFNames=AO090011000417;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=30466366; DOI=10.1080/09168451.2018.1549934;
RA   Shinohara Y., Nishimura I., Koyama Y.;
RT   "Identification of a gene cluster for biosynthesis of the sesquiterpene
RT   antibiotic, heptelidic acid, in Aspergillus oryzae.";
RL   Biosci. Biotechnol. Biochem. 83:1506-1513(2019).
CC   -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC       the biosynthesis of heptelidic acid (HA), a sesquiterpene lactone that
CC       acts as an inhibitor of glyceraldehyde-3-phosphatedehydrogenase (GAPDH)
CC       and a growth inhibitor of the salt-tolerant lactic acid bacteria in soy
CC       sauce brewing (PubMed:30466366). Both hepR and hepS regulate the
CC       transcription of the heptelidic acid cluster, but they are not involved
CC       in mutual transcriptional regulation and act with different mechanisms
CC       (PubMed:30466366). {ECO:0000269|PubMed:30466366}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:30466366}.
CC   -!- DISRUPTION PHENOTYPE: Reduces markedly the expression of hepA and
CC       abolishes the production of heptelidic acid.
CC       {ECO:0000269|PubMed:30466366}.
CC   -!- SIMILARITY: Belongs to the TRI10 transcription regulator family.
CC       {ECO:0000305}.
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DR   EMBL; AP007171; BAE64921.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2U0J4; -.
DR   EnsemblFungi; BAE64921; BAE64921; AO090011000417.
DR   VEuPathDB; FungiDB:AO090011000417; -.
DR   HOGENOM; CLU_019313_1_1_1; -.
DR   OMA; GCMASES; -.
DR   Proteomes; UP000006564; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021858; Fun_TF.
DR   Pfam; PF11951; Fungal_trans_2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..429
FT                   /note="Transcription factor hepS"
FT                   /id="PRO_0000450836"
SQ   SEQUENCE   429 AA;  48181 MW;  1AC1D70CCFD50022 CRC64;
     MISMSVPRKK QEREISLLMH YVDDVFPHQF PIYHSQFVGK REWLLPLLSS TRSVYYATLC
     LSLLHKEKSS NLDQPGSVSF CQEERLRYYI LALRETQQLL QQLSPVCDLE AMRSCVPSLA
     SALHLISYES SCPVYGDWKV HLQAATSLIP ILVGGWNSMI KPIKHTSTLW TGLTLSDFHD
     LHTEGSLSYE DASALRFLTN ALAVTGILSF ISTGPTSALS DYRYLMDATC DMVQCDQFLG
     CENWVMSAIL DVGLLDRWKR EEEGNRRLSF RELANRAKRL EDCLENGIRE LSAKTSGSSD
     AVSSITRIYA SSTLTYLHSV VSGLNPDLSE IQESVSRTIE LLKELSNWHL LACLTWPLCV
     TGCMAAPDHE AFFHSLAISA EISPHSLRHT WIVLRILKDV GKVRGSLGEQ ILPTWEQILC
     IDGAPILLT