ID   HERP2_BOVIN             Reviewed;         406 AA.
AC   Q0P5H8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN   Name=HERPUD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC       pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120015; AAI20016.1; -; mRNA.
DR   RefSeq; NP_001069026.1; NM_001075558.1.
DR   AlphaFoldDB; Q0P5H8; -.
DR   BMRB; Q0P5H8; -.
DR   SMR; Q0P5H8; -.
DR   STRING; 9913.ENSBTAP00000020101; -.
DR   PaxDb; Q0P5H8; -.
DR   PRIDE; Q0P5H8; -.
DR   Ensembl; ENSBTAT00000020101; ENSBTAP00000020101; ENSBTAG00000015105.
DR   GeneID; 512265; -.
DR   KEGG; bta:512265; -.
DR   CTD; 64224; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015105; -.
DR   VGNC; VGNC:29817; HERPUD2.
DR   eggNOG; KOG4583; Eukaryota.
DR   GeneTree; ENSGT00390000017671; -.
DR   HOGENOM; CLU_058243_0_0_1; -.
DR   InParanoid; Q0P5H8; -.
DR   OMA; LYNAWMS; -.
DR   OrthoDB; 1251727at2759; -.
DR   TreeFam; TF324319; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000015105; Expressed in omental fat pad and 104 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   InterPro; IPR039751; HERPUD1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12943; PTHR12943; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Unfolded protein response.
FT   CHAIN           1..406
FT                   /note="Homocysteine-responsive endoplasmic reticulum-
FT                   resident ubiquitin-like domain member 2 protein"
FT                   /id="PRO_0000280626"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..89
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          86..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45164 MW;  C920559652D9C397 CRC64;
     MDQNGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
     RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN RESHEALASN SNSSSDQSGS
     STPSSSQETL TLATSSSSEG LRQRTLPQAQ TDPAQSHQVP YVMQGNVDNQ LPGQAVPAGF
     PVYPAFNPLQ MLWWQQMYAH QYYMQYQAAV SAQATSNANP AQPAATQPLN LAHVPGEEPP
     PAPNLVAQEN RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
     RFIMVMGAML LVYLHQAGWF PFRQEGVQHQ APNNNAEVNN DVQNANNLEL EEMERLMDDG
     LEDESGEDAG EDASAIQRPG LMASAWSFIT TFFTSLIPEG PPQVAN