ID   HERP2_DANRE             Reviewed;         397 AA.
AC   Q6NYI0; Q7ZVH0;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN   Name=herpud2; ORFNames=zgc:56020, zgc:76968;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC       pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC045865; AAH45865.1; -; mRNA.
DR   EMBL; BC066585; AAH66585.1; -; mRNA.
DR   RefSeq; NP_956482.1; NM_200188.1.
DR   AlphaFoldDB; Q6NYI0; -.
DR   SMR; Q6NYI0; -.
DR   STRING; 7955.ENSDARP00000038769; -.
DR   PaxDb; Q6NYI0; -.
DR   GeneID; 393157; -.
DR   KEGG; dre:393157; -.
DR   CTD; 64224; -.
DR   ZFIN; ZDB-GENE-040426-868; herpud2.
DR   eggNOG; KOG4583; Eukaryota.
DR   InParanoid; Q6NYI0; -.
DR   OrthoDB; 1251727at2759; -.
DR   PhylomeDB; Q6NYI0; -.
DR   PRO; PR:Q6NYI0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   InterPro; IPR039751; HERPUD1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12943; PTHR12943; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Unfolded protein response.
FT   CHAIN           1..397
FT                   /note="Homocysteine-responsive endoplasmic reticulum-
FT                   resident ubiquitin-like domain member 2 protein"
FT                   /id="PRO_0000280630"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..89
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          87..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..242
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..358
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        36
FT                   /note="K -> E (in Ref. 1; AAH45865)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        97
FT                   /note="S -> T (in Ref. 1; AAH45865)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="T -> A (in Ref. 1; AAH45865)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        217
FT                   /note="A -> P (in Ref. 1; AAH45865)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   397 AA;  43730 MW;  96F392DAE8D2CC6B CRC64;
     MDQGTVDSPV TLVIKAPNQK YDDQTINCFL NWTVEKLKKH ISNVYPSKPL SKDQRLVYSG
     RLLQDHLQLR DVLRKQDEYH MVHLVCASRS PPSSPTSDSH FSTTDSSSST SDSAGPSLSS
     TPSQEAQANS DGLRHRGNPA ATHGLNPAPT GVMQRPEGMP LPMQGGPAAG FPTHPMYMPM
     QMFWWQQMYA RHYYVQYQAA IAASRASSVA PSPSLSAGPA TQPVQPNEPA APMGPNPAPE
     DRPANPNIQM NAQGGAMLND DELNRDWLDW MYTVSRAAIL LSIVYFYSSF GRFVMVIGAM
     LLVYLHQAGW FPFRAELQNP RAEEGAQDEA DQNQDMQEME RMMDEGIEDD EGDSGEEGPD
     DPMNPGPHQP GFLSATWSFI STFFTSLIPE GPPQAAN