HERP2_HUMAN
ID HERP2_HUMAN Reviewed; 406 AA.
AC Q9BSE4; A4D1Y8; Q9H6F9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN Name=HERPUD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney epithelium, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-108.
RC TISSUE=Colon, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP STRUCTURE BY NMR OF 9-85.
RG Northeast structural genomics consortium (NESG);
RT "Structure of human homocysteine-inducible, endoplasmic reticulum stress-
RT inducible, ubiquitin-like domain member 2 (HERPUD2 or HERP).";
RL Submitted (MAY-2012) to the PDB data bank.
CC -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC pathway. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BSE4; Q5BKT4: ALG10; NbExp=3; IntAct=EBI-2868124, EBI-13064220;
CC Q9BSE4; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-2868124, EBI-10269179;
CC Q9BSE4; P52803: EFNA5; NbExp=3; IntAct=EBI-2868124, EBI-1753674;
CC Q9BSE4; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-2868124, EBI-725665;
CC Q9BSE4; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-2868124, EBI-12070086;
CC Q9BSE4; Q96HR8: NAF1; NbExp=3; IntAct=EBI-2868124, EBI-2515597;
CC Q9BSE4; Q96G79: SLC35A4; NbExp=3; IntAct=EBI-2868124, EBI-12363689;
CC Q9BSE4; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-2868124, EBI-2823239;
CC Q9BSE4; P30825: SLC7A1; NbExp=3; IntAct=EBI-2868124, EBI-4289564;
CC Q9BSE4; Q969W0: SPTSSA; NbExp=3; IntAct=EBI-2868124, EBI-723396;
CC Q9BSE4; Q9NYW0: TAS2R10; NbExp=3; IntAct=EBI-2868124, EBI-12963900;
CC Q9BSE4; P55061: TMBIM6; NbExp=5; IntAct=EBI-2868124, EBI-1045825;
CC Q9BSE4; Q7Z5S9: TMEM144; NbExp=3; IntAct=EBI-2868124, EBI-12876358;
CC Q9BSE4; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-2868124, EBI-2852148;
CC Q9BSE4; P63146: UBE2B; NbExp=3; IntAct=EBI-2868124, EBI-712629;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK055708; BAG51558.1; -; mRNA.
DR EMBL; AK315685; BAG38050.1; -; mRNA.
DR EMBL; AC018647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236951; EAL23973.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW94051.1; -; Genomic_DNA.
DR EMBL; BC005091; AAH05091.1; -; mRNA.
DR EMBL; BC020264; AAH20264.1; -; mRNA.
DR EMBL; AK025966; BAB15300.1; -; mRNA.
DR CCDS; CCDS5446.1; -.
DR RefSeq; NP_071768.3; NM_022373.4.
DR RefSeq; XP_016867995.1; XM_017012506.1.
DR PDB; 2KDB; NMR; -; A=9-85.
DR PDBsum; 2KDB; -.
DR AlphaFoldDB; Q9BSE4; -.
DR BMRB; Q9BSE4; -.
DR SMR; Q9BSE4; -.
DR BioGRID; 122114; 23.
DR IntAct; Q9BSE4; 21.
DR STRING; 9606.ENSP00000379390; -.
DR iPTMnet; Q9BSE4; -.
DR PhosphoSitePlus; Q9BSE4; -.
DR BioMuta; HERPUD2; -.
DR DMDM; 296434524; -.
DR EPD; Q9BSE4; -.
DR jPOST; Q9BSE4; -.
DR MassIVE; Q9BSE4; -.
DR MaxQB; Q9BSE4; -.
DR PaxDb; Q9BSE4; -.
DR PeptideAtlas; Q9BSE4; -.
DR PRIDE; Q9BSE4; -.
DR ProteomicsDB; 78881; -.
DR Antibodypedia; 2395; 110 antibodies from 23 providers.
DR DNASU; 64224; -.
DR Ensembl; ENST00000311350.8; ENSP00000310729.3; ENSG00000122557.11.
DR Ensembl; ENST00000396081.5; ENSP00000379390.1; ENSG00000122557.11.
DR GeneID; 64224; -.
DR KEGG; hsa:64224; -.
DR MANE-Select; ENST00000311350.8; ENSP00000310729.3; NM_022373.5; NP_071768.3.
DR UCSC; uc003tes.5; human.
DR CTD; 64224; -.
DR DisGeNET; 64224; -.
DR GeneCards; HERPUD2; -.
DR HGNC; HGNC:21915; HERPUD2.
DR HPA; ENSG00000122557; Low tissue specificity.
DR neXtProt; NX_Q9BSE4; -.
DR OpenTargets; ENSG00000122557; -.
DR PharmGKB; PA144596425; -.
DR VEuPathDB; HostDB:ENSG00000122557; -.
DR eggNOG; KOG4583; Eukaryota.
DR GeneTree; ENSGT00390000017671; -.
DR HOGENOM; CLU_058243_0_0_1; -.
DR InParanoid; Q9BSE4; -.
DR OMA; LYNAWMS; -.
DR OrthoDB; 1251727at2759; -.
DR PhylomeDB; Q9BSE4; -.
DR TreeFam; TF324319; -.
DR PathwayCommons; Q9BSE4; -.
DR SignaLink; Q9BSE4; -.
DR BioGRID-ORCS; 64224; 17 hits in 1071 CRISPR screens.
DR ChiTaRS; HERPUD2; human.
DR EvolutionaryTrace; Q9BSE4; -.
DR GenomeRNAi; 64224; -.
DR Pharos; Q9BSE4; Tdark.
DR PRO; PR:Q9BSE4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BSE4; protein.
DR Bgee; ENSG00000122557; Expressed in cauda epididymis and 196 other tissues.
DR ExpressionAtlas; Q9BSE4; baseline and differential.
DR Genevisible; Q9BSE4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR039751; HERPUD1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12943; PTHR12943; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Unfolded protein response.
FT CHAIN 1..406
FT /note="Homocysteine-responsive endoplasmic reticulum-
FT resident ubiquitin-like domain member 2 protein"
FT /id="PRO_0000280627"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 10..89
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 86..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 108
FT /note="A -> T (in dbSNP:rs3779234)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031182"
FT VARIANT 200
FT /note="H -> L (in dbSNP:rs2305335)"
FT /id="VAR_031183"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:2KDB"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:2KDB"
FT STRAND 24..28
FT /evidence="ECO:0007829|PDB:2KDB"
FT HELIX 34..44
FT /evidence="ECO:0007829|PDB:2KDB"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:2KDB"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:2KDB"
FT STRAND 61..63
FT /evidence="ECO:0007829|PDB:2KDB"
FT HELIX 70..73
FT /evidence="ECO:0007829|PDB:2KDB"
FT TURN 74..76
FT /evidence="ECO:0007829|PDB:2KDB"
FT STRAND 78..84
FT /evidence="ECO:0007829|PDB:2KDB"
SQ SEQUENCE 406 AA; 45147 MW; E21BDCB03E1CD08A CRC64;
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
RLLPDHLQLK DILRKQDEYH MVHLVCTSRT PPSSPKSSTN RESHEALASS SNSSSDHSGS
TTPSSGQETL SLAVGSSSEG LRQRTLPQAQ TDQAQSHQFP YVMQGNVDNQ FPGQAAPPGF
PVYPAFSPLQ MLWWQQMYAH QYYMQYQAAV SAQATSNVNP TQPTTSQPLN LAHVPGEEPP
PAPNLVAQEN RPMNENVQMN AQGGPVLNEE DFNRDWLDWM YTFSRAAILL SIVYFYSSFS
RFIMVMGAML LVYLHQAGWF PFRQEGGHQQ APNNNAEVNN DGQNANNLEL EEMERLMDDG
LEDESGEDGG EDASAIQRPG LMASAWSFIT TFFTSLIPEG PPQVAN
