HERP2_MOUSE
ID HERP2_MOUSE Reviewed; 404 AA.
AC Q9JJC9; Q8K2W2; Q9CSZ4; Q9D2D0;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN Name=Herpud2; ORFNames=MNCb-2040;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg, Embryo, Ovary, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC pathway. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AB041580; BAA95064.1; -; mRNA.
DR EMBL; AK011625; BAB27742.1; -; mRNA.
DR EMBL; AK019862; BAB31889.1; -; mRNA.
DR EMBL; AK135935; BAE22730.1; -; mRNA.
DR EMBL; BC029691; AAH29691.1; -; mRNA.
DR EMBL; BC043693; AAH43693.1; -; mRNA.
DR CCDS; CCDS22934.1; -.
DR RefSeq; NP_065611.1; NM_020586.2.
DR AlphaFoldDB; Q9JJC9; -.
DR BMRB; Q9JJC9; -.
DR SMR; Q9JJC9; -.
DR STRING; 10090.ENSMUSP00000008573; -.
DR iPTMnet; Q9JJC9; -.
DR PhosphoSitePlus; Q9JJC9; -.
DR jPOST; Q9JJC9; -.
DR MaxQB; Q9JJC9; -.
DR PaxDb; Q9JJC9; -.
DR PeptideAtlas; Q9JJC9; -.
DR PRIDE; Q9JJC9; -.
DR ProteomicsDB; 269700; -.
DR Antibodypedia; 2395; 110 antibodies from 23 providers.
DR DNASU; 80517; -.
DR Ensembl; ENSMUST00000008573; ENSMUSP00000008573; ENSMUSG00000008429.
DR GeneID; 80517; -.
DR KEGG; mmu:80517; -.
DR UCSC; uc009oph.2; mouse.
DR CTD; 64224; -.
DR MGI; MGI:1915393; Herpud2.
DR VEuPathDB; HostDB:ENSMUSG00000008429; -.
DR eggNOG; KOG4583; Eukaryota.
DR GeneTree; ENSGT00390000017671; -.
DR HOGENOM; CLU_058243_0_0_1; -.
DR InParanoid; Q9JJC9; -.
DR OMA; LYNAWMS; -.
DR OrthoDB; 1251727at2759; -.
DR PhylomeDB; Q9JJC9; -.
DR TreeFam; TF324319; -.
DR BioGRID-ORCS; 80517; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Herpud2; mouse.
DR PRO; PR:Q9JJC9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9JJC9; protein.
DR Bgee; ENSMUSG00000008429; Expressed in secondary oocyte and 252 other tissues.
DR Genevisible; Q9JJC9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEP:BHF-UCL.
DR InterPro; IPR039751; HERPUD1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12943; PTHR12943; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Unfolded protein response.
FT CHAIN 1..404
FT /note="Homocysteine-responsive endoplasmic reticulum-
FT resident ubiquitin-like domain member 2 protein"
FT /id="PRO_0000280628"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 10..89
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 86..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 218
FT /note="G -> S (in Ref. 3; AAH29691)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="N -> K (in Ref. 2; BAB31889)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="D -> P (in Ref. 2; BAB27742)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 44501 MW; EECBEEEB7ADD76C7 CRC64;
MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
RLLPDHLQLK DILRKQDEYH MVHLVCASRS PPSSPKSSTD RGSHEALASS TSSNSDHSDS
TTPSPSQESL SLVTGSSEGL RQRTLSQAQT DPAQSHQFPY VIQGNVDHQF PGQGVPPAFP
VYPALSPLQM LWWQQMYAHQ YYMQYQAAVS AQATSSAGSA QRAASSPLNL AHVPGEEPPP
APNLVAQENG PMNENVQMNA QGGPVLNEED LNRDWLDWVY TFSRAAVLLS IVYFYSSFSR
FIMVMGAMLL VYLHQAGWFP FRQEGGQQQA PNNVDANNDG HNANNLELEE MERLMDDGLE
DESGEDAGED ASAAQRPGLM ASAWSFITTF FTSLIPEGPP QVAN
