ID   HERP2_RAT               Reviewed;         401 AA.
AC   Q66HH4;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN   Name=Herpud2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC       pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC081861; AAH81861.1; -; mRNA.
DR   RefSeq; NP_001020159.1; NM_001024988.1.
DR   AlphaFoldDB; Q66HH4; -.
DR   BMRB; Q66HH4; -.
DR   SMR; Q66HH4; -.
DR   STRING; 10116.ENSRNOP00000049139; -.
DR   PaxDb; Q66HH4; -.
DR   GeneID; 300463; -.
DR   KEGG; rno:300463; -.
DR   UCSC; RGD:1307343; rat.
DR   CTD; 64224; -.
DR   RGD; 1307343; Herpud2.
DR   VEuPathDB; HostDB:ENSRNOG00000029995; -.
DR   eggNOG; KOG4583; Eukaryota.
DR   HOGENOM; CLU_058243_0_0_1; -.
DR   InParanoid; Q66HH4; -.
DR   OMA; LYNAWMS; -.
DR   OrthoDB; 1251727at2759; -.
DR   PRO; PR:Q66HH4; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000029995; Expressed in testis and 18 other tissues.
DR   Genevisible; Q66HH4; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   InterPro; IPR039751; HERPUD1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12943; PTHR12943; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Unfolded protein response.
FT   CHAIN           1..401
FT                   /note="Homocysteine-responsive endoplasmic reticulum-
FT                   resident ubiquitin-like domain member 2 protein"
FT                   /id="PRO_0000280629"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..89
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          87..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  44151 MW;  7162BB5FC72CAD4F CRC64;
     MDQSGMEIPV TLIIKAPNQK YSDQTISCFL NWTVGKLKTH LSNVYPSKPL TKDQRLVYSG
     RLLPDHLQLK DILRKQDEYH MVHLVCASRS PPSSPKSSTD GESHGALASS TNSNSDHSDS
     TTPSPSQESL SLVAGSSEGL RHRTLPQAQT DPAQSHQFPY VIQGNVDHQF PGQGVPPGFP
     MYPAFSPLQM LWWQQMYAQQ YYMQYQAAVT AQATSSASSA QHAASSPLNL AHVPGEEPPP
     APNLVAQENG PENVQMNAQG GPVLNEEDFN RDWLDWVYTF SRAAVLLSIV YFYSSFSRFI
     MVMGAMLLVY LHQAGWFPFR QEGGQQQAPN NVDANNEGQN ANNLELEEMR LMDDGLEDES
     GEDAGEDASA AQRPGLMASA WSFITTFFTS LIPEGPPQVA N