ID   HERP2_XENLA             Reviewed;         398 AA.
AC   Q7ZXQ3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN   Name=herpud2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC       pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC044318; AAH44318.1; -; mRNA.
DR   RefSeq; NP_001079560.1; NM_001086091.1.
DR   AlphaFoldDB; Q7ZXQ3; -.
DR   SMR; Q7ZXQ3; -.
DR   DNASU; 379247; -.
DR   GeneID; 379247; -.
DR   KEGG; xla:379247; -.
DR   CTD; 379247; -.
DR   Xenbase; XB-GENE-6256358; herpud2.L.
DR   OMA; LYNAWMS; -.
DR   OrthoDB; 1251727at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 379247; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR   InterPro; IPR039751; HERPUD1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12943; PTHR12943; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Unfolded protein response.
FT   CHAIN           1..398
FT                   /note="Homocysteine-responsive endoplasmic reticulum-
FT                   resident ubiquitin-like domain member 2 protein"
FT                   /id="PRO_0000280631"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          11..90
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          90..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..246
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  44393 MW;  EC5338C58ABC43D4 CRC64;
     MTCQPVMDCP VTLVIKAPNQ KYDDQTINCF LDWTVEKLKS HLSKVYPSKP SAKDQRLVYS
     GKLLLDHLLL KDVLRKQDEY HMVHLVCASR TPPSSPKASK SSKSMGTSSS GRSSSSGSAN
     PGSTSQDTSS TYPDPRPGES IRHRHTPLMY NNLVHSHPYS YLRQEYALNP PPGQEAPSIF
     PAYSAFTPLQ MMWWQQLYAR QYYIYSQATA SNQSTSNGEN AQPVPRPVTN SENPPPNPPR
     APPNVAPEIN PNIQMNAQGG PVMNEEDINR DWLDWIYTVS RAAILLSIVY FYSSFSRFVM
     VMGALILVYM HQAGWFPLLQ DEGQQHPGDN AAEVNPDLVN NNDPQELERR MDDGLQEVHN
     NDAGVNVVAR QGVLASAWSF ITTFFTSLIP EGPPQGVN