ID   HERP2_XENTR             Reviewed;         399 AA.
AC   Q28DF1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein;
GN   Name=herpud2; ORFNames=TEgg004b20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could be involved in the unfolded protein response (UPR)
CC       pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CR855549; CAJ81769.1; -; mRNA.
DR   RefSeq; NP_001016818.1; NM_001016818.2.
DR   RefSeq; XP_012820186.1; XM_012964732.2.
DR   RefSeq; XP_012820187.1; XM_012964733.1.
DR   AlphaFoldDB; Q28DF1; -.
DR   SMR; Q28DF1; -.
DR   STRING; 8364.ENSXETP00000005147; -.
DR   PaxDb; Q28DF1; -.
DR   Ensembl; ENSXETT00000028711; ENSXETP00000028711; ENSXETG00000013111.
DR   GeneID; 549572; -.
DR   KEGG; xtr:549572; -.
DR   CTD; 64224; -.
DR   Xenbase; XB-GENE-5806725; herpud2.
DR   eggNOG; KOG4583; Eukaryota.
DR   HOGENOM; CLU_058243_0_0_1; -.
DR   InParanoid; Q28DF1; -.
DR   OrthoDB; 1251727at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013111; Expressed in skeletal muscle tissue and 13 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   InterPro; IPR039751; HERPUD1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12943; PTHR12943; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Unfolded protein response.
FT   CHAIN           1..399
FT                   /note="Homocysteine-responsive endoplasmic reticulum-
FT                   resident ubiquitin-like domain member 2 protein"
FT                   /id="PRO_0000280632"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..89
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          88..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..247
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  44724 MW;  936DC2B85250ED74 CRC64;
     MDQPVMDCPV TLVIKAPNQK YDDQTINCFL DWTVEKLKSH LSKVYPSKPL AKDQRLVYSG
     KLLLDHLLLK DVLRKQDEYH MVHLVCASRT PPSSPKASTS NKSMGTASIS RSSSEHSGSA
     SPASIRQDTS STYPDPRPGD SIRHRHTSLM YNNLVHSHPF SYLRQEYALN PPPGQASPST
     FPAYSAFTPL QMMWWQQLYA RQYYIYSQAT ASNQSPSNGE NAQPVPRPVI NSESPPPNPP
     RAPPNVAPEM NPNIQMNAQG GPVMNEEDIN RDWLDWMYTV SRAAILLSIV YFYSSFSRFV
     MVMGAMILVY MHQAGWFPLL QDEGQQHARD NAAEVNPDHV NNNDPQELEH RMDEGLQEEH
     NNNAGGNVVA RRGVLASAWS FITTFFTSLI PEGPPQGAN