HES1_CHICK
ID HES1_CHICK Reviewed; 290 AA.
AC O57337;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription factor HES-1;
DE AltName: Full=C-HAIRY1;
DE AltName: Full=Hairy and enhancer of split 1;
GN Name=HES1; Synonyms=HAIRY1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=9393857; DOI=10.1016/s0092-8674(00)80451-1;
RA Palmeirim I., Henrique D., Ish-Horowicz D., Pourquie O.;
RT "Avian hairy gene expression identifies a molecular clock linked to
RT vertebrate segmentation and somitogenesis.";
RL Cell 91:639-648(1997).
CC -!- FUNCTION: Transcriptional repressor of genes that require a bHLH
CC protein for their transcription. May act as a negative regulator of
CC myogenesis by inhibiting the functions of MYOD1 and ASH1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein of the Groucho/TLE family. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Strongly expressed in the presomitic mesoderm,
CC where its mRNA exhibits cyclic waves of expression whose temporal
CC periodicity corresponds to the formation time of one somite (90 min).
CC -!- DOMAIN: Has a particular type of basic domain (presence of a helix-
CC interrupting proline) that binds to the N-box (CACNAG), rather than the
CC canonical E-box (CANNTG).
CC -!- DOMAIN: The C-terminal WRPW motif is a transcriptional repression
CC domain necessary for the interaction with Groucho/TLE family members,
CC transcriptional corepressors recruited to specific target DNA by Hairy-
CC related proteins. {ECO:0000250}.
CC -!- DOMAIN: The bHLH, as well as cooperation between the central Orange
CC domain and the C-terminal WRPW motif, is required for transcriptional
CC repressor activity. {ECO:0000250}.
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DR EMBL; AF032966; AAB88691.1; -; mRNA.
DR AlphaFoldDB; O57337; -.
DR SMR; O57337; -.
DR ELM; O57337; -.
DR VEuPathDB; HostDB:geneid_395128; -.
DR InParanoid; O57337; -.
DR PhylomeDB; O57337; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEP:AgBase.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..290
FT /note="Transcription factor HES-1"
FT /id="PRO_0000127205"
FT DOMAIN 35..92
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 111..144
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 287..290
FT /note="WRPW motif"
FT COMPBIAS 28..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 290 AA; 31072 MW; FC78F01884896F67 CRC64;
MPADTGMEKP TASPIAGAPA SASHTPDKPR SASEHRKSSK PIMEKRRRAR INESLGQLKM
LILDALKKDS SRHSKLEKAD ILEMTVKHLR NLQRAQMAAA LSADPSVLGK YRAGFNECMN
EVTRFLSTCE GVNADVRARL LGHLSACLGQ IVAMNYLPPP PAGQPAHLAQ PLHVQLPPTT
TGAVPVPCKL EPTEALSPKV YGGFQLVPAT DGQFAFLIPN PAFPPGSGPV IPLYANANVP
VSTAWRSSER VHPPAGIPGA GLDIIWARVV PASQAGSPIA ERREAVWRPW
