ID   ANM7_AEDAE              Reviewed;         686 AA.
AC   Q16NS8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein arginine N-methyltransferase 7;
DE            EC=2.1.1.-;
GN   Name=Art7; ORFNames=AAEL011877;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Essential arginine methyltransferase that can both catalyze
CC       the formation of omega-N monomethylarginine (MMA) and symmetrical
CC       dimethylarginine (sDMA). Specifically mediates the symmetrical
CC       dimethylation of arginine residues in the small nuclear
CC       ribonucleoproteins SmD1 and SmD3 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Protein arginine N-methyltransferase family. PRMT7
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01015}.
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DR   EMBL; CH477810; EAT36004.1; -; Genomic_DNA.
DR   RefSeq; XP_001662010.1; XM_001661960.1.
DR   AlphaFoldDB; Q16NS8; -.
DR   SMR; Q16NS8; -.
DR   STRING; 7159.AAEL011877-PA; -.
DR   GeneID; 5575498; -.
DR   KEGG; aag:5575498; -.
DR   VEuPathDB; VectorBase:AAEL011877; -.
DR   eggNOG; KOG1501; Eukaryota.
DR   HOGENOM; CLU_015180_0_0_1; -.
DR   InParanoid; Q16NS8; -.
DR   OMA; LPMANCA; -.
DR   OrthoDB; 408622at2759; -.
DR   PhylomeDB; Q16NS8; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0018216; P:peptidyl-arginine methylation; ISS:UniProtKB.
DR   GO; GO:0035247; P:peptidyl-arginine omega-N-methylation; IEA:UniProt.
DR   Gene3D; 3.40.50.150; -; 2.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR014644; MeTrfase_PRMT7.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PTHR11006; 1.
DR   PIRSF; PIRSF036946; Arg_N-mtase; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   PROSITE; PS51678; SAM_MT_PRMT; 2.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..686
FT                   /note="Protein arginine N-methyltransferase 7"
FT                   /id="PRO_0000373908"
FT   DOMAIN          5..352
FT                   /note="SAM-dependent MTase PRMT-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT   DOMAIN          357..686
FT                   /note="SAM-dependent MTase PRMT-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
SQ   SEQUENCE   686 AA;  77396 MW;  57A8293C560F64C3 CRC64;
     MHSDSDDYFS GDDDDFDRQQ EIARSAFADM CHDWERNQKY DRALQLTIER LHCEGKEAHV
     LDIGTGSGLL SMMAVRAGAD SVTACEAFRP MADCAERVIA SNGMGDRIRL VKKKSTELKV
     GAGKDMERKA NVLVTELFDT ELIGEGAIAT YRHALQFLLE EGCRVIPDKA TVFAQVVECP
     LAMSWQTPKL LCSSDGDVLL RVPEEMVNCR GSSAVFDVQL SQLPLESFNA LSEPIPVFEF
     DWSSREALKF KRHSRNLLKV QSSGIPQAVF MWWDLKMDLE GTVLLSCAPF WAHPDFEGLK
     TQKQNDSIPE PNLIPWRDHW MQAIYFLPHS KTPLAKGEEI ALDAFHDEFS WWFGLNDLSL
     DPGHCSCGMH IAYSRSRIGQ LNDGPRNKRI LNYLEEVLDK NSVVLVLGDG SLLGLSIRAM
     GAKKVILVET NQTSRHCMER FVEHNGLENV EILSCLDDLT PDATADITHI FGEPFFTSAI
     LPWENAIQFI WELNRVKALL NHEVSVIPHS FSIYGVAVEF LDLQKISAPL GTCEGFDLSL
     MDRMIEEHSK VADSPVEAQP LWEYPCLPLG PKCKMITINV AEGSQNQLEQ GKITLTRHHE
     IKECNGIALW AEWHMGKNVS PKNTISSGPL SVIDEASELP VRPLQWNSNW RQGVHLLRKP
     LEESKMFLSW TVKYNAQLKT CYFKFD