HES5_RAT
ID HES5_RAT Reviewed; 166 AA.
AC Q03062;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Transcription factor HES-5;
DE AltName: Full=Hairy and enhancer of split 5;
GN Name=Hes5; Synonyms=Hes-5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=1400497; DOI=10.1016/s0021-9258(19)36694-3;
RA Akazawa C., Sasai Y., Nakanishi S., Kageyama R.;
RT "Molecular characterization of a rat negative regulator with a basic helix-
RT loop-helix structure predominantly expressed in the developing nervous
RT system.";
RL J. Biol. Chem. 267:21879-21885(1992).
CC -!- FUNCTION: Transcriptional repressor of genes that require a bHLH
CC protein for their transcription. Plays an important role as
CC neurogenesis negative regulator (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein of the Groucho/TLE family. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in embryonic neural lineage
CC cells. {ECO:0000269|PubMed:1400497}.
CC -!- DOMAIN: Has a particular type of basic domain (presence of a helix-
CC interrupting proline) that binds to the N-box (CACNAG), rather than the
CC canonical E-box (CANNTG).
CC -!- DOMAIN: The C-terminal WRPW motif is a transcriptional repression
CC domain necessary for the interaction with Groucho/TLE family members,
CC transcriptional corepressors recruited to specific target DNA by Hairy-
CC related proteins. {ECO:0000250}.
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DR EMBL; D12516; BAA02081.1; -; mRNA.
DR PIR; A45119; A45119.
DR RefSeq; NP_077359.1; NM_024383.1.
DR AlphaFoldDB; Q03062; -.
DR SMR; Q03062; -.
DR ELM; Q03062; -.
DR IntAct; Q03062; 2.
DR MINT; Q03062; -.
DR STRING; 10116.ENSRNOP00000018769; -.
DR PaxDb; Q03062; -.
DR PRIDE; Q03062; -.
DR Ensembl; ENSRNOT00000018769; ENSRNOP00000018769; ENSRNOG00000013850.
DR GeneID; 79225; -.
DR KEGG; rno:79225; -.
DR CTD; 388585; -.
DR RGD; 621340; Hes5.
DR eggNOG; ENOG502S6S1; Eukaryota.
DR GeneTree; ENSGT00940000162836; -.
DR HOGENOM; CLU_068550_3_1_1; -.
DR InParanoid; Q03062; -.
DR OMA; LSHCEVQ; -.
DR OrthoDB; 1378299at2759; -.
DR PhylomeDB; Q03062; -.
DR TreeFam; TF351373; -.
DR PRO; PR:Q03062; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000013850; Expressed in frontal cortex and 7 other tissues.
DR Genevisible; Q03062; RN.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048708; P:astrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0043010; P:camera-type eye development; ISS:UniProtKB.
DR GO; GO:0051216; P:cartilage development; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; ISS:UniProtKB.
DR GO; GO:0048469; P:cell maturation; ISS:UniProtKB.
DR GO; GO:0022010; P:central nervous system myelination; ISS:UniProtKB.
DR GO; GO:0072049; P:comma-shaped body morphogenesis; ISO:RGD.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; ISO:RGD.
DR GO; GO:0021861; P:forebrain radial glial cell differentiation; IDA:UniProtKB.
DR GO; GO:0021781; P:glial cell fate commitment; ISS:UniProtKB.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR GO; GO:0060122; P:inner ear receptor cell stereocilium organization; ISO:RGD.
DR GO; GO:0072282; P:metanephric nephron tubule morphogenesis; ISO:RGD.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; ISS:UniProtKB.
DR GO; GO:2000978; P:negative regulation of forebrain neuron differentiation; IDA:UniProtKB.
DR GO; GO:0045608; P:negative regulation of inner ear auditory receptor cell differentiation; ISO:RGD.
DR GO; GO:2000981; P:negative regulation of inner ear receptor cell differentiation; ISO:RGD.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR GO; GO:2000974; P:negative regulation of pro-B cell differentiation; IMP:UniProtKB.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:RGD.
DR GO; GO:0021915; P:neural tube development; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IEP:RGD.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IDA:UniProtKB.
DR GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISO:RGD.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:UniProtKB.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
DR GO; GO:0065003; P:protein-containing complex assembly; ISS:UniProtKB.
DR GO; GO:0045595; P:regulation of cell differentiation; ISS:UniProtKB.
DR GO; GO:0050678; P:regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0031641; P:regulation of myelination; ISS:UniProtKB.
DR GO; GO:0050767; P:regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0072050; P:S-shaped body morphogenesis; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; ISS:UniProtKB.
DR GO; GO:0072086; P:specification of loop of Henle identity; ISO:RGD.
DR GO; GO:0021537; P:telencephalon development; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..166
FT /note="Transcription factor HES-5"
FT /id="PRO_0000127213"
FT DOMAIN 16..72
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 88..119
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 125..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 163..166
FT /note="WRPW motif"
FT COMPBIAS 138..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 166 AA; 18452 MW; CAA5046F07B1B0C1 CRC64;
MAPSTVAVEM LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD
ILEMAVSYLK HSKAFAAAAG PKSLHQDYSE GYSWCLQEAV QFLTLHAASD TQMKLLYHFQ
RPPAPAAPVK ETPTPGAAPQ PARSSTKAAA SVSTSRQSAC GLWRPW
