ID   HES71_XENTR             Reviewed;         178 AA.
AC   Q28HA8;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Transcription factor HES-7.1;
DE   AltName: Full=Hairy and enhancer of split 7.1;
GN   Name=hes7.1; ORFNames=TEgg019e05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82070.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg {ECO:0000312|EMBL:CAJ82070.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. Represses transcription from both
CC       N box- and E box-containing promoters. Demarcates the prospective
CC       midbrain-hindbrain boundary (MHB) region in the neuroectoderm in early
CC       gastrulae embryos by repressing transcription of a number of target
CC       genes (By similarity). {ECO:0000250|UniProtKB:Q8BKT2,
CC       ECO:0000250|UniProtKB:Q8UW74}.
CC   -!- SUBUNIT: Transcription repression requires formation of a complex with
CC       a corepressor protein of the Groucho/TLE family.
CC       {ECO:0000250|UniProtKB:P14003}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BKT2,
CC       ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-
CC       ProRule:PRU00981}.
CC   -!- DOMAIN: Has a particular type of basic domain which includes a helix-
CC       interrupting proline.
CC   -!- DOMAIN: The C-terminal WRPW motif is a transcriptional repression
CC       domain necessary for the interaction with Groucho/TLE family members,
CC       transcriptional corepressors recruited to specific target DNA by Hairy-
CC       related proteins. {ECO:0000250|UniProtKB:P14003}.
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DR   EMBL; CR760960; CAJ82070.1; -; mRNA.
DR   RefSeq; NP_001039166.1; NM_001045701.1.
DR   AlphaFoldDB; Q28HA8; -.
DR   SMR; Q28HA8; -.
DR   STRING; 8364.ENSXETP00000019915; -.
DR   PaxDb; Q28HA8; -.
DR   GeneID; 733997; -.
DR   KEGG; xtr:733997; -.
DR   CTD; 733997; -.
DR   Xenbase; XB-GENE-876465; hes7.1.
DR   eggNOG; KOG4304; Eukaryota.
DR   HOGENOM; CLU_068550_6_1_1; -.
DR   InParanoid; Q28HA8; -.
DR   OMA; MEAHRKL; -.
DR   OrthoDB; 1172143at2759; -.
DR   PhylomeDB; Q28HA8; -.
DR   TreeFam; TF351373; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009079; Expressed in egg cell and 9 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0030917; P:midbrain-hindbrain boundary development; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR032644; HES-7.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   PANTHER; PTHR10985:SF84; PTHR10985:SF84; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..178
FT                   /note="Transcription factor HES-7.1"
FT                   /id="PRO_0000370217"
FT   DOMAIN          13..70
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   DOMAIN          84..116
FT                   /note="Orange"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT   REGION          122..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           174..177
FT                   /note="WRPW motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   178 AA;  20129 MW;  C28D4DF2E4E70E37 CRC64;
     MKGASEVRPM EAHRKLLKPL VERRRRERIN NSLEKLRIFL SQALKSEKLK NPKVEKAEIL
     ECTVQFLQSS KLVPQDGDVG NKGYQSGFQH CLETALHFMN SKPDLNVATK DFLSHQLSSY
     KPPAEAWSPT DTPKPTPSIG YQDSAPHLSS NTISVSPTKT LVDGQFSPQT FQTWRPWV