ID   HESA1_TRIV2             Reviewed;         267 AA.
AC   P46049; Q3M643;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Protein HesA, heterocyst;
GN   Name=hesA1; OrderedLocusNames=Ava_3938;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-267.
RX   PubMed=8709854; DOI=10.1111/j.1365-2958.1995.mmi_18020357.x;
RA   Schrautemeier B., Neveling U., Schmitz S.;
RT   "Distinct and differently regulated Mo-dependent nitrogen-fixing systems
RT   evolved for heterocysts and vegetative cells of Anabaena variabilis ATCC
RT   29413: characterization of the fdxH1/2 gene regions as part of the nif1/2
RT   gene clusters.";
RL   Mol. Microbiol. 18:357-369(1995).
CC   -!- DEVELOPMENTAL STAGE: Expressed exclusively within heterocysts.
CC   -!- SIMILARITY: Belongs to the HesA/MoeB/ThiF family. {ECO:0000305}.
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DR   EMBL; CP000117; ABA23543.1; -; Genomic_DNA.
DR   EMBL; Z46887; CAA86984.1; -; Genomic_DNA.
DR   PIR; S70242; S70242.
DR   AlphaFoldDB; P46049; -.
DR   SMR; P46049; -.
DR   STRING; 240292.Ava_3938; -.
DR   EnsemblBacteria; ABA23543; ABA23543; Ava_3938.
DR   KEGG; ava:Ava_3938; -.
DR   eggNOG; COG0476; Bacteria.
DR   HOGENOM; CLU_013325_10_0_3; -.
DR   OMA; SAKWKLE; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0043158; P:heterocyst differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953; PTHR10953; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   2: Evidence at transcript level;
KW   Heterocyst; Nitrogen fixation.
FT   CHAIN           1..267
FT                   /note="Protein HesA, heterocyst"
FT                   /id="PRO_0000120571"
SQ   SEQUENCE   267 AA;  29495 MW;  4F4A641C4483D0FC CRC64;
     MINLTPTELE RYSRQMMLPN FGEAAQKRLK SATVLVTGVG GLGGTAALYL AVAGVGRLIL
     VRGGDLRLDD MNRQVLMTDD WVGKPRVFKA KETLQAINPD IQIETIHDYV TSDNVDSLVQ
     SADMALDCAH NFTERDLLNS ACVRWRKPMV EAAMDGMEAY LTTIIPGVTP CLSCIFPEKP
     EWDRRGFSVL GAVSGTLACL TALEAIKLIT GFSQPLLSQL LTIDLNRMEF AKRRLYRDRS
     CPVCGNDAPW RYAQSNSMET SSNCTHS