ID   HESX1_PANPA             Reviewed;         185 AA.
AC   A1YGA2;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Homeobox expressed in ES cells 1;
GN   Name=HESX1;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the normal development of the forebrain, eyes
CC       and other anterior structures such as the olfactory placodes and
CC       pituitary gland. Possible transcriptional repressor. Binds to the
CC       palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1
CC       and PROP1 bind as heterodimers on this palindromic site, and, in vitro,
CC       HESX1 can antagonize PROP1 activation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Can form heterodimers with PROP1 in binding to DNA. Interacts
CC       with TLE1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the ANF homeobox family. {ECO:0000305}.
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DR   EMBL; DQ977246; ABM54327.1; -; Genomic_DNA.
DR   RefSeq; XP_008970304.1; XM_008972056.2.
DR   AlphaFoldDB; A1YGA2; -.
DR   SMR; A1YGA2; -.
DR   STRING; 9597.XP_003818759.1; -.
DR   GeneID; 100967444; -.
DR   KEGG; pps:100967444; -.
DR   CTD; 8820; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0021983; P:pituitary gland development; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR043402; Hesx1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR46966; PTHR46966; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="Homeobox expressed in ES cells 1"
FT                   /id="PRO_0000285447"
FT   DNA_BIND        108..167
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   185 AA;  21382 MW;  E60755CD9E9791E8 CRC64;
     MSPSLQEGAQ LGESKPSTCS FSIERILGLD QKKDCVPLMK PHRPWADTCS SSGKDGNLCL
     HVPNPPSGIS FPSVVDHPMP EERASKYENY FSASERLSLK RELSWYRGRR PRTAFTQNQI
     EVLENVFRVN CYPGIDIRED LAQKLNLEED RIQIWFQNRR AKLKRSHRES QFLMAKKNFN
     TNLLE