ID   HESX1_PANTR             Reviewed;         185 AA.
AC   A2T777;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Homeobox expressed in ES cells 1;
GN   Name=HESX1;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the normal development of the forebrain, eyes
CC       and other anterior structures such as the olfactory placodes and
CC       pituitary gland. Possible transcriptional repressor. Binds to the
CC       palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1
CC       and PROP1 bind as heterodimers on this palindromic site, and, in vitro,
CC       HESX1 can antagonize PROP1 activation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Can form heterodimers with PROP1 in binding to DNA. Interacts
CC       with TLE1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the ANF homeobox family. {ECO:0000305}.
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DR   EMBL; DQ977388; ABM92032.1; -; Genomic_DNA.
DR   RefSeq; NP_001075039.1; NM_001081570.1.
DR   RefSeq; XP_009443736.1; XM_009445461.2.
DR   RefSeq; XP_009443737.1; XM_009445462.2.
DR   RefSeq; XP_016795536.1; XM_016940047.1.
DR   RefSeq; XP_016795537.1; XM_016940048.1.
DR   AlphaFoldDB; A2T777; -.
DR   SMR; A2T777; -.
DR   STRING; 9598.ENSPTRP00000025986; -.
DR   PaxDb; A2T777; -.
DR   Ensembl; ENSPTRT00000028167; ENSPTRP00000025986; ENSPTRG00000015044.
DR   GeneID; 747229; -.
DR   KEGG; ptr:747229; -.
DR   CTD; 8820; -.
DR   VGNC; VGNC:1836; HESX1.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000156780; -.
DR   HOGENOM; CLU_125528_0_0_1; -.
DR   InParanoid; A2T777; -.
DR   OMA; MDACTNL; -.
DR   OrthoDB; 1270742at2759; -.
DR   TreeFam; TF335506; -.
DR   Proteomes; UP000002277; Chromosome 3.
DR   Bgee; ENSPTRG00000015044; Expressed in testis and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0008406; P:gonad development; IEA:Ensembl.
DR   GO; GO:0048861; P:leukemia inhibitory factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0043584; P:nose development; IEA:Ensembl.
DR   GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
DR   GO; GO:0021983; P:pituitary gland development; ISS:UniProtKB.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR   GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR043402; Hesx1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR46966; PTHR46966; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="Homeobox expressed in ES cells 1"
FT                   /id="PRO_0000285448"
FT   DNA_BIND        108..167
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   185 AA;  21394 MW;  B3FF437EAD691255 CRC64;
     MSPSLQEGAQ LGESKPSTCS FSIERILGLD QNKDCVPLMK PHRPWADTCS SSGKDGNLCL
     HVPNPPSGIS FPSVVDHPMP EERALKYENY FSASERLSLK RELSWYRGRR PRTAFTQNQI
     EVLENVFRVN CYPGIDIRED LAQKLNLEED RIQIWFQNRR AKLKRSHRES QFLMAKKNFN
     TNLLE