ID   HESX1_RABIT             Reviewed;         175 AA.
AC   O97670;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Homeobox expressed in ES cells 1;
DE   AltName: Full=Homeobox protein ANF;
DE   Flags: Fragment;
GN   Name=HESX1; Synonyms=ANF;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RA   Mitchell S.A., Viebahn C., Blum M.;
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the normal development of the forebrain, eyes
CC       and other anterior structures such as the olfactory placodes and
CC       pituitary gland. Possible transcriptional repressor. Binds to the
CC       palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'.
CC   -!- SUBUNIT: Interacts with TLE1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the ANF homeobox family. {ECO:0000305}.
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DR   EMBL; AF102132; AAD11791.1; -; mRNA.
DR   AlphaFoldDB; O97670; -.
DR   SMR; O97670; -.
DR   STRING; 9986.ENSOCUP00000005167; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; O97670; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0021983; P:pituitary gland development; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR043402; Hesx1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR46966; PTHR46966; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..>175
FT                   /note="Homeobox expressed in ES cells 1"
FT                   /id="PRO_0000048924"
FT   DNA_BIND        108..167
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         175
SQ   SEQUENCE   175 AA;  20312 MW;  63E6300C6F4B3CA2 CRC64;
     MSPNLQEGAR LVEGKPSSTS FSIESILGLD QKKDDAPSMK PHRPWADTCS SLGKDANLRL
     HVPSFPNGIS FPHPGDHPMP EERAMKYENY FSASERASLK RELNWYRGRR PRTAFTQNQV
     EVLENVFRVN CYPGIDIRED LARKLNLEED RIQIWFQNRR AKLKRSHRES QFLMA