ID   HET6_NEUCR              Reviewed;         680 AA.
AC   Q9UV10; Q7RVQ1;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Heterokaryon incompatibility protein 6, OR allele;
DE            Short=Het-6(OR);
GN   Name=het-6; ORFNames=B2A19.100, NCU03533;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10880472; DOI=10.1093/genetics/155.3.1095;
RA   Smith M.L., Micali O.C., Hubbard S.P., Mir-Rashed N., Jacobson D.J.,
RA   Glass N.L.;
RT   "Vegetative incompatibility in the het-6 region of Neurospora crassa is
RT   mediated by two linked genes.";
RL   Genetics 155:1095-1104(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in the non-self-recognition during asexual growth of
CC       N.crassa. This process involves restriction of heterokaryon formation
CC       via genetic differences at 11 het loci, including mating type.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF206700; AAF18141.1; -; Genomic_DNA.
DR   EMBL; AL390092; CAB98240.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA27576.3; -; Genomic_DNA.
DR   PIR; T51076; T51076.
DR   RefSeq; XP_956812.3; XM_951719.3.
DR   AlphaFoldDB; Q9UV10; -.
DR   STRING; 5141.EFNCRP00000002679; -.
DR   EnsemblFungi; EAA27576; EAA27576; NCU03533.
DR   GeneID; 3872950; -.
DR   KEGG; ncr:NCU03533; -.
DR   VEuPathDB; FungiDB:NCU03533; -.
DR   HOGENOM; CLU_877680_0_0_1; -.
DR   InParanoid; Q9UV10; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   InterPro; IPR010730; HET.
DR   Pfam; PF06985; HET; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..680
FT                   /note="Heterokaryon incompatibility protein 6, OR allele"
FT                   /id="PRO_0000083952"
SQ   SEQUENCE   680 AA;  77868 MW;  F79066AD0B5C95D7 CRC64;
     MANSAQTDTV SAGNLFSYDS VALSDPSTHI RLLDLHPASC YTDDLYCCIY TAPISPPPSY
     IALSYVWGDS TRTHEISVAN EVNDGRAFIP LRLTSSLDTC LRHLRELHYR RQLEPLPLWI
     DQICINQDDN EEKSFQVRLM RDIYSSAHQV VVWLGPAVDD SNRVMDALAE VGQEFLDKIG
     DHTEEEHWLS VDRLIKEKIE QPDAVTFLRE AYKVIYMLNR EHSFTRWVER TWFKRLWTIQ
     EFCLCADTIF ACGYKVVSQK MVSALTDFMR CIIMDKCLRG LLETPDTPTY STLFSGLMRL
     FPLFQHRGYC QYPYRKETLE HLLVELFVGV TPPCVTNKRD KVYGLLGLAG DADELGIRPD
     YTTSTTLAQV FTQTARAIIQ KNWKIQRKRG LQILRYGSLG QRKSAPKNET DLPSWVPEWN
     GRIAKTYQRE MSFLACGEIR MPDLVPTTSP TILGLRGFCV GTIVDLGEQA RVDIWRRSAD
     GAKKIVGFFD NFRRLLNLSK QNKRAKDIYA STAHHDAALW RVPIGDQHII FGVGRQIAKR
     TDSKEDSAFQ NFIAYYEDYV RRDDDWKDYM AAYQAGEEQA KLKMGKHMDR VFSEGYYMGL
     RHMEGKRPYL TENGYLGMGP GLLQPGDKVV VFHGDDIPYV VRPVPGKGDN TYLLMGEAYC
     DGIMDGELAD TAEREDFYLV