HETE1_PODAS
ID HETE1_PODAS Reviewed; 1356 AA.
AC Q00808;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Vegetative incompatibility protein HET-E-1;
GN Name=HET-E1;
OS Podospora anserina (Pleurage anserina).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Podosporaceae; Podospora.
OX NCBI_TaxID=2587412;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7557402; DOI=10.1016/0378-1119(95)00272-8;
RA Saupe S., Turcq B., Begueret J.;
RT "A gene responsible for vegetative incompatibility in the fungus Podospora
RT anserina encodes a protein with a GTP-binding motif and G beta homologous
RT domain.";
RL Gene 162:135-139(1995).
CC -!- FUNCTION: Responsible for vegetative incompatibility through specific
CC interactions with different alleles of the unlinked gene, het-c.
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DR EMBL; L28125; AAA85775.1; -; Genomic_DNA.
DR PIR; T18521; T18521.
DR AlphaFoldDB; Q00808; -.
DR SMR; Q00808; -.
DR VEuPathDB; FungiDB:PODANS_7_3110; -.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 5.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR010730; HET.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF06985; HET; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00400; WD40; 10.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; SSF50978; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 10.
DR PROSITE; PS50082; WD_REPEATS_2; 10.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW GTP-binding; Nucleotide-binding; Repeat; WD repeat.
FT CHAIN 1..1356
FT /note="Vegetative incompatibility protein HET-E-1"
FT /id="PRO_0000051015"
FT DOMAIN 294..629
FT /note="NACHT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT REPEAT 839..869
FT /note="WD 1"
FT REPEAT 881..911
FT /note="WD 2"
FT REPEAT 923..953
FT /note="WD 3"
FT REPEAT 965..995
FT /note="WD 4"
FT REPEAT 1007..1037
FT /note="WD 5"
FT REPEAT 1049..1079
FT /note="WD 6"
FT REPEAT 1091..1121
FT /note="WD 7"
FT REPEAT 1133..1163
FT /note="WD 8"
FT REPEAT 1175..1205
FT /note="WD 9"
FT REPEAT 1217..1247
FT /note="WD 10"
FT BINDING 300..307
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1356 AA; 149766 MW; 965FB319844E0651 CRC64;
MRLLERDDAG EIRPTKDLPS GKIPPYAILS HTWGPDEEEV SYKDLKDGRA VSKLGYNKIR
FCADQAWRDG RKFFWVDTCC IDKSNSTELQ EAINSMFRWY RDAAKCYVYL TDVSTDKRDA
DGDPSWKWAF QKCKWFTRGW TLQELIAPTS VEFFSREKAR IGDRNSLERM IHDVTGIPLE
ALRGSPLSDF SVHDRMAWMK QRNTTREEDM AYSLFGIFDV HLPLIYGEGK EKALERLREK
IGKDDGCLAD LRVTDPRHDK KRIEAAKGGL LKDSYCWVLS NVQFQQWHDG DDQRLLWING
DPGKGKTMLL CGIIDELKKS TPPGLLSFFF CQATDSRINN ATAVLRGLIY LLVSQQPALI
SHVRRPYDHA GKKMFEGPNV WIVLCEIFTS ILQDPGLRMT YLIIDALDEC VTDLPQLLEL
ITRTSCTSSP IKWIVSSRNW PDIEEQLETA TQKARLSLEL NAESISTAVN AFIQNRIDQL
APKTKHDANM IGKIRDYLHS HANGTFLWVA LVCQALADPK VKKRHILAKL QTFPRGLDSL
YARMLEQIGH SEDAELCKQI LAVAAAVRRP ISLDELASLV EMPDDVSDDP ESLEEIVKLC
GSFLIIRERT VYFVHQSAKD FLLGTASDKA SNKASQEAFE LVFPTGIEDV SYIIFWRSLN
VMSQKLRRDI YCLNAPGFLI DNVRVPDPDP LATVRYSCIY WIDHLRDLVS STSSKWVHLL
QDDGDIHRFL TTKYLYWLEA LSLLRALPEG INAIRQLESL LGHTIRGRLI AIVRDGYRFA
LSYRMIIEKA PLQAYTSALV FAPTDSMIKK IFKKEEPGWI STISVVEAEW NACTQTLEGH
GSSVLSVAFS ADGQRVASGS DDKTIKIWDT ASGTGTQTLE GHGGSVWSVA FSPDRERVAS
GSDDKTIKIW DAASGTCTQT LEGHGGRVQS VAFSPDGQRV ASGSDDHTIK IWDAASGTCT
QTLEGHGSSV LSVAFSPDGQ RVASGSGDKT IKIWDTASGT CTQTLEGHGG SVWSVAFSPD
GQRVASGSDD KTIKIWDTAS GTCTQTLEGH GGWVQSVVFS PDGQRVASGS DDHTIKIWDA
VSGTCTQTLE GHGDSVWSVA FSPDGQRVAS GSIDGTIKIW DAASGTCTQT LEGHGGWVHS
VAFSPDGQRV ASGSIDGTIK IWDAASGTCT QTLEGHGGWV QSVAFSPDGQ RVASGSSDKT
IKIWDTASGT CTQTLEGHGG WVQSVAFSPD GQRVASGSSD NTIKIWDTAS GTCTQTLNVG
STATCLSFDY TNAYINTNIG RIQIATATME SLNQLSSPVC YSYGLGQDHR WITCNNQNVL
WLPPEYHTSA FTMQGRKIVL GSYSGRIIIF LFSRDV