ID   HETE1_PODAS             Reviewed;        1356 AA.
AC   Q00808;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Vegetative incompatibility protein HET-E-1;
GN   Name=HET-E1;
OS   Podospora anserina (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora.
OX   NCBI_TaxID=2587412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7557402; DOI=10.1016/0378-1119(95)00272-8;
RA   Saupe S., Turcq B., Begueret J.;
RT   "A gene responsible for vegetative incompatibility in the fungus Podospora
RT   anserina encodes a protein with a GTP-binding motif and G beta homologous
RT   domain.";
RL   Gene 162:135-139(1995).
CC   -!- FUNCTION: Responsible for vegetative incompatibility through specific
CC       interactions with different alleles of the unlinked gene, het-c.
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DR   EMBL; L28125; AAA85775.1; -; Genomic_DNA.
DR   PIR; T18521; T18521.
DR   AlphaFoldDB; Q00808; -.
DR   SMR; Q00808; -.
DR   VEuPathDB; FungiDB:PODANS_7_3110; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 5.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR010730; HET.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF06985; HET; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF00400; WD40; 10.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 10.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50837; NACHT; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 10.
DR   PROSITE; PS50082; WD_REPEATS_2; 10.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   GTP-binding; Nucleotide-binding; Repeat; WD repeat.
FT   CHAIN           1..1356
FT                   /note="Vegetative incompatibility protein HET-E-1"
FT                   /id="PRO_0000051015"
FT   DOMAIN          294..629
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   REPEAT          839..869
FT                   /note="WD 1"
FT   REPEAT          881..911
FT                   /note="WD 2"
FT   REPEAT          923..953
FT                   /note="WD 3"
FT   REPEAT          965..995
FT                   /note="WD 4"
FT   REPEAT          1007..1037
FT                   /note="WD 5"
FT   REPEAT          1049..1079
FT                   /note="WD 6"
FT   REPEAT          1091..1121
FT                   /note="WD 7"
FT   REPEAT          1133..1163
FT                   /note="WD 8"
FT   REPEAT          1175..1205
FT                   /note="WD 9"
FT   REPEAT          1217..1247
FT                   /note="WD 10"
FT   BINDING         300..307
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1356 AA;  149766 MW;  965FB319844E0651 CRC64;
     MRLLERDDAG EIRPTKDLPS GKIPPYAILS HTWGPDEEEV SYKDLKDGRA VSKLGYNKIR
     FCADQAWRDG RKFFWVDTCC IDKSNSTELQ EAINSMFRWY RDAAKCYVYL TDVSTDKRDA
     DGDPSWKWAF QKCKWFTRGW TLQELIAPTS VEFFSREKAR IGDRNSLERM IHDVTGIPLE
     ALRGSPLSDF SVHDRMAWMK QRNTTREEDM AYSLFGIFDV HLPLIYGEGK EKALERLREK
     IGKDDGCLAD LRVTDPRHDK KRIEAAKGGL LKDSYCWVLS NVQFQQWHDG DDQRLLWING
     DPGKGKTMLL CGIIDELKKS TPPGLLSFFF CQATDSRINN ATAVLRGLIY LLVSQQPALI
     SHVRRPYDHA GKKMFEGPNV WIVLCEIFTS ILQDPGLRMT YLIIDALDEC VTDLPQLLEL
     ITRTSCTSSP IKWIVSSRNW PDIEEQLETA TQKARLSLEL NAESISTAVN AFIQNRIDQL
     APKTKHDANM IGKIRDYLHS HANGTFLWVA LVCQALADPK VKKRHILAKL QTFPRGLDSL
     YARMLEQIGH SEDAELCKQI LAVAAAVRRP ISLDELASLV EMPDDVSDDP ESLEEIVKLC
     GSFLIIRERT VYFVHQSAKD FLLGTASDKA SNKASQEAFE LVFPTGIEDV SYIIFWRSLN
     VMSQKLRRDI YCLNAPGFLI DNVRVPDPDP LATVRYSCIY WIDHLRDLVS STSSKWVHLL
     QDDGDIHRFL TTKYLYWLEA LSLLRALPEG INAIRQLESL LGHTIRGRLI AIVRDGYRFA
     LSYRMIIEKA PLQAYTSALV FAPTDSMIKK IFKKEEPGWI STISVVEAEW NACTQTLEGH
     GSSVLSVAFS ADGQRVASGS DDKTIKIWDT ASGTGTQTLE GHGGSVWSVA FSPDRERVAS
     GSDDKTIKIW DAASGTCTQT LEGHGGRVQS VAFSPDGQRV ASGSDDHTIK IWDAASGTCT
     QTLEGHGSSV LSVAFSPDGQ RVASGSGDKT IKIWDTASGT CTQTLEGHGG SVWSVAFSPD
     GQRVASGSDD KTIKIWDTAS GTCTQTLEGH GGWVQSVVFS PDGQRVASGS DDHTIKIWDA
     VSGTCTQTLE GHGDSVWSVA FSPDGQRVAS GSIDGTIKIW DAASGTCTQT LEGHGGWVHS
     VAFSPDGQRV ASGSIDGTIK IWDAASGTCT QTLEGHGGWV QSVAFSPDGQ RVASGSSDKT
     IKIWDTASGT CTQTLEGHGG WVQSVAFSPD GQRVASGSSD NTIKIWDTAS GTCTQTLNVG
     STATCLSFDY TNAYINTNIG RIQIATATME SLNQLSSPVC YSYGLGQDHR WITCNNQNVL
     WLPPEYHTSA FTMQGRKIVL GSYSGRIIIF LFSRDV