ID   HETM_NOSS1              Reviewed;         506 AA.
AC   P37693; Q44211;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Polyketide synthase HetM;
GN   Name=hetM; OrderedLocusNames=alr5357;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8157596; DOI=10.1128/jb.176.8.2282-2292.1994;
RA   Black T.A., Wolk C.P.;
RT   "Analysis of a Het- mutation in Anabaena sp. strain PCC 7120 implicates a
RT   secondary metabolite in the regulation of heterocyst spacing.";
RL   J. Bacteriol. 176:2282-2292(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bauer C.C., Ramaswamy K.S., Endley S., Golden J.W., Haselkorn R.;
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 phosphopantetheine covalently. {ECO:0000250};
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DR   EMBL; L22883; AAA22001.1; -; Genomic_DNA.
DR   EMBL; U04436; AAA03658.1; -; Unassigned_DNA.
DR   EMBL; BA000019; BAB77056.1; -; Genomic_DNA.
DR   PIR; AE2475; AE2475.
DR   PIR; B55210; B55210.
DR   RefSeq; WP_010999481.1; NZ_RSCN01000005.1.
DR   AlphaFoldDB; P37693; -.
DR   SMR; P37693; -.
DR   STRING; 103690.17134496; -.
DR   EnsemblBacteria; BAB77056; BAB77056; BAB77056.
DR   KEGG; ana:alr5357; -.
DR   eggNOG; COG0236; Bacteria.
DR   eggNOG; COG3320; Bacteria.
DR   OMA; HDFINLM; -.
DR   OrthoDB; 1928091at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd05235; SDR_e1; 1.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01746; Thioester-redct; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Oxidoreductase; Phosphopantetheine;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..506
FT                   /note="Polyketide synthase HetM"
FT                   /id="PRO_0000180296"
FT   DOMAIN          10..84
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         44
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   CONFLICT        442
FT                   /note="F -> L (in Ref. 2; AAA03658)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   506 AA;  55767 MW;  A99A0CAE3A7665B8 CRC64;
     MSLKQNYSAA DIQAWMISNL AELLGVDGDE IDATVNLESY GLDSAQAMVL VSKLEQLLGF
     QPSPLLLWHY PTIESLSERL AEELEEQSEE QNTDSATANH SNGTPVLDLQ AEVVLDPVIH
     PGGAIPVDFP VTQPKKVFLT GGTGFLGAFL IRELLQQTQA DVYCLVRAAD AQAGKAKIQT
     NLEGYAIWQE EYESRIIPVV GDLAEPLLGL SSTQFQALAA EIDTIYHSGA LLNYVFPYSA
     LKAANVLGTQ EVLRLACQIK VKPVHYVSSV AVFESPVYAG KVVKESDDFS HWEGIFLGYS
     QTKWVAEKLV KIAGDRGLPV TIHRPPLIGG DSETGIGNTH DFINLMVKGC LQMGCFPDVE
     YMLDMSPVDY VSKAIVHLSM QKESLGKAFH LQHPEPVSLS VLVDWVRSFG YEIKTLPYEE
     WQAELINNAT SVDNPLYTLR PFLLERWSDE QLTIPDLYLK AKRPHISCQD TLKALAGTSI
     GCPPIDGKLF MTYTAYLIQT GFLTLA