ANM7_CAEEL
ID ANM7_CAEEL Reviewed; 647 AA.
AC Q9XW42;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein arginine N-methyltransferase 7;
DE EC=2.1.1.-;
GN Name=prmt-7; Synonyms=pmrt-2; ORFNames=W06D4.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=19521535; DOI=10.1371/journal.pgen.1000514;
RA Yang M., Sun J., Sun X., Shen Q., Gao Z., Yang C.;
RT "Caenorhabditis elegans protein arginine methyltransferase PRMT-5
RT negatively regulates DNA damage-induced apoptosis.";
RL PLoS Genet. 5:E1000514-E1000514(2009).
CC -!- FUNCTION: Arginine methyltransferase that can both catalyze the
CC formation of omega-N monomethylarginine (MMA) and symmetrical
CC dimethylarginine (sDMA). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Protein arginine N-methyltransferase family. PRMT7
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01015}.
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DR EMBL; AL034364; CAA22252.2; -; Genomic_DNA.
DR PIR; T26236; T26236.
DR RefSeq; NP_492436.2; NM_060035.3.
DR PDB; 3WST; X-ray; 2.39 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-647.
DR PDB; 3X0D; X-ray; 2.15 A; A=1-647.
DR PDBsum; 3WST; -.
DR PDBsum; 3X0D; -.
DR AlphaFoldDB; Q9XW42; -.
DR SMR; Q9XW42; -.
DR BioGRID; 38159; 1.
DR STRING; 6239.W06D4.4; -.
DR EPD; Q9XW42; -.
DR PaxDb; Q9XW42; -.
DR PeptideAtlas; Q9XW42; -.
DR EnsemblMetazoa; W06D4.4.1; W06D4.4.1; WBGene00012298.
DR GeneID; 172727; -.
DR KEGG; cel:CELE_W06D4.4; -.
DR UCSC; W06D4.4.1; c. elegans.
DR CTD; 172727; -.
DR WormBase; W06D4.4; CE45537; WBGene00012298; prmt-7.
DR eggNOG; KOG1501; Eukaryota.
DR GeneTree; ENSGT00940000156879; -.
DR HOGENOM; CLU_015180_0_0_1; -.
DR InParanoid; Q9XW42; -.
DR OMA; LPMANCA; -.
DR OrthoDB; 408622at2759; -.
DR PhylomeDB; Q9XW42; -.
DR BRENDA; 2.1.1.321; 1045.
DR Reactome; R-CEL-3214858; RMTs methylate histone arginines.
DR PRO; PR:Q9XW42; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00012298; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IBA:GO_Central.
DR GO; GO:0035247; P:peptidyl-arginine omega-N-methylation; IEA:UniProt.
DR Gene3D; 3.40.50.150; -; 2.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR014644; MeTrfase_PRMT7.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006; PTHR11006; 1.
DR PIRSF; PIRSF036946; Arg_N-mtase; 1.
DR SUPFAM; SSF53335; SSF53335; 2.
DR PROSITE; PS51678; SAM_MT_PRMT; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Methyltransferase; Reference proteome; Repeat;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..647
FT /note="Protein arginine N-methyltransferase 7"
FT /id="PRO_0000373907"
FT DOMAIN 12..332
FT /note="SAM-dependent MTase PRMT-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT DOMAIN 337..647
FT /note="SAM-dependent MTase PRMT-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT ACT_SITE 140
FT /evidence="ECO:0000250"
FT ACT_SITE 149
FT /evidence="ECO:0000250"
FT STRAND 3..6
FT /evidence="ECO:0007829|PDB:3WST"
FT TURN 8..10
FT /evidence="ECO:0007829|PDB:3WST"
FT STRAND 13..16
FT /evidence="ECO:0007829|PDB:3WST"
FT HELIX 19..21
FT /evidence="ECO:0007829|PDB:3WST"
FT HELIX 22..30
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 31..35
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 36..38
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 40..60
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 61..63
FT /evidence="ECO:0007829|PDB:3WST"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 77..84
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 88..93
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 97..108
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 111..115
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 116..119
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 123..125
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 134..139
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 151..161
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 163..171
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 173..182
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 184..187
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 188..190
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 223..225
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 233..239
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 243..245
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 248..257
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 266..280
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 282..284
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 288..290
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 292..294
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 299..301
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 303..306
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 319..326
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 331..334
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 346..348
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 349..352
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 355..365
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 368..378
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 381..386
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 392..396
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 397..399
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 401..406
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 410..422
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 428..432
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 434..436
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 442..445
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 456..460
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 461..472
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 478..481
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 483..488
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 491..495
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 496..499
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 512..525
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 528..532
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 534..536
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 539..541
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 546..552
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 560..567
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 569..571
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 574..583
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 586..595
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 601..603
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 609..612
FT /evidence="ECO:0007829|PDB:3X0D"
FT HELIX 616..618
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 622..630
FT /evidence="ECO:0007829|PDB:3X0D"
FT TURN 632..634
FT /evidence="ECO:0007829|PDB:3X0D"
FT STRAND 637..642
FT /evidence="ECO:0007829|PDB:3X0D"
SQ SEQUENCE 647 AA; 73326 MW; 7281F8E7CE65CFAB CRC64;
MFLEKINQKT GEREWVVAEE DYDMAQELAR SRFGDMILDF DRNDKFLAGL KTTIAEKKHE
NTDGKVHVLD IGTGTGLLSL MAAREGADKV TALEVFKPMG DCARHITSNS PWSDKITVIS
ERSTDVSQIG GSRADIIVAE VFDTELIGEG ALRTFKEALE RLAKPGCRVV PSTGNVYIVP
VESHLLKMFN DIPRLNGEKD EEPLGRCSGT AAVFDVQLSE MKTHEFRELS EPIVAFKFDF
EHEEKIIFDE SFVREAVAHS SGTIDALLMW WDIDMDRNGT TFIDMGPKWK NKNNYAWRDH
WMQAVYYLPE KKKVEMNQTF EIVCNHDEFS LWFSNVGKDK SRSYCVCGLH SMLSRQTVYH
VNEMFENQKF KDEVDKLSKG LHVATVGEGS FLGLLAAKTA KRVTIIDGNE RFRDIFFKYI
HYYKLTNVEI IEKVTSLTDS PDIVLAEPFY MSAMNPWNHL RFLYDVEVLK MMHGDELRVE
PHMGVLKAIP EKFEDLQNIA SDVGTVNGFD LSFFDEISTK ARTATDAIVD EQSLWEYAGI
VKGDAVEILR FPIDGRVSSQ KCVVNIDNMS SSNAIPMWME WEFGGINLST GLLSISSAGV
PEWNKGYKQG VYFPITALRN DKSLCLHALF DKSTGDINFQ FGKSEDS
