ID   HETR_NOSS9              Reviewed;         298 AA.
AC   Q51320;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=DNA-binding transcriptional activator HetR {ECO:0000255|HAMAP-Rule:MF_00781};
DE            EC=3.4.21.- {ECO:0000255|HAMAP-Rule:MF_00781};
DE   AltName: Full=Heterocyst differentiation control protein {ECO:0000255|HAMAP-Rule:MF_00781};
GN   Name=hetR {ECO:0000255|HAMAP-Rule:MF_00781};
OS   Nostoc sp. (strain PCC 9229).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=70817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Matveyev A.V., Lotti F., Bergman B.;
RT   "The hetR gene, required for heterocyst differentiation from a symbiotic
RT   cyanobacterium Nostoc sp. PCC 9229: cloning, sequencing and expression.";
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Controls heterocyst differentiation. Dimerization is required
CC       for DNA-binding. Has both a protease and a DNA-binding activity.
CC       {ECO:0000255|HAMAP-Rule:MF_00781}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000255|HAMAP-
CC       Rule:MF_00781}.
CC   -!- SIMILARITY: Belongs to the peptidase S48 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00781}.
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DR   EMBL; X92989; CAA63577.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q51320; -.
DR   SMR; Q51320; -.
DR   MEROPS; S48.001; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043158; P:heterocyst differentiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1670; -; 1.
DR   Gene3D; 1.10.10.1680; -; 1.
DR   HAMAP; MF_00781; HetR; 1.
DR   InterPro; IPR040949; HetR_C.
DR   InterPro; IPR041936; HetR_DNA-bd_N.
DR   InterPro; IPR041935; HetR_flap.
DR   InterPro; IPR005319; Pept_S48_HetR.
DR   Pfam; PF18460; HetR_C; 1.
DR   Pfam; PF03574; Peptidase_S48; 1.
PE   3: Inferred from homology;
KW   Activator; Disulfide bond; DNA-binding; Heterocyst; Hydrolase; Protease;
KW   Serine protease; Transcription; Transcription regulation.
FT   CHAIN           1..298
FT                   /note="DNA-binding transcriptional activator HetR"
FT                   /id="PRO_0000208481"
FT   ACT_SITE        152
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00781"
FT   DISULFID        48
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00781"
SQ   SEQUENCE   298 AA;  34463 MW;  87CA38EB09B459CF CRC64;
     MSNDIDLINR LGPSAMDQDH AYLAFSAMRT SGHRHGAFLD AAATAAKCAI YMTYLEQGQN
     LRMTGHLHHL EPKRVKIIVE EVRQALTEGK LLKMLGSQEP RYLIQLPYVW LEKYPWQPGR
     SRVPGTSLTS EEKRQIEQKL PSNLPDAQLV SSFEFLDLIE FLHKRSQEDL PPEHQMPLSQ
     ALGEHIKRRL LYSGTVTRID SPWGMPFYAL TRPFYAPADD QERTYIMVED TARYFRMMKN
     WAERRRNAMR LLEELDILPE NGASYEELDE VIRAWADKYH QDGGIAVVLQ TAFGERED