ID   HEX6_RICCO              Reviewed;         510 AA.
AC   Q07423;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 84.
DE   RecName: Full=Hexose carrier protein HEX6;
GN   Name=HEX6;
OS   Ricinus communis (Castor bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Ricinus.
OX   NCBI_TaxID=3988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Carmencita; TISSUE=Cotyledon;
RA   Weig A., Franz J., Sauer N., Komor E.;
RT   "Isolation of a family of cDNA-clones from Ricinus communis L. with close
RT   homology to the hexose carriers.";
RL   J. Plant Physiol. 143:178-183(1994).
CC   -!- FUNCTION: Active uptake of hexoses. Probable glucose/hydrogen symport.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; L08188; AAA79857.1; -; mRNA.
DR   PIR; T10124; T10124.
DR   RefSeq; NP_001310704.1; NM_001323775.1.
DR   STRING; 3988.XP_002510991.1; -.
DR   GeneID; 8289638; -.
DR   KEGG; rcu:8289638; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   InParanoid; Q07423; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   CDD; cd17361; MFS_STP; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR044778; MFS_STP/MST-like_plant.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR045262; STP/PLT_plant.
DR   InterPro; IPR003663; Sugar/inositol_transpt.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   PANTHER; PTHR23500; PTHR23500; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR00171; SUGRTRNSPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00879; SP; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR   PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Sugar transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..510
FT                   /note="Hexose carrier protein HEX6"
FT                   /id="PRO_0000050445"
FT   TOPO_DOM        1..22
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        23..43
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        472..510
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   510 AA;  55597 MW;  26615F8EBD84299E CRC64;
     MAAGLAITSE GGQYNGRMTS FVALSCMMAA MGGVIFGYDI GVSGGVTSMD PFLKKFFPDV
     YRKMKEDTEI SNYCKFDSQL LTSFTSSLYV AGLVASFFAS SVTRAFGRKP SILLGGXVFL
     AXAALGGAAV NVYMLIFGRV LLGVGVGFAN QAVPLYLSEM APPRYRGAIN NGFQFSVGIG
     ALSANLINYG TEKIEGGWGW RISLAMAAVP AAILTFGALF LPETPNSLIQ RSNDHERAKL
     MLQRVRGTTD VQAELDDLIK ASIISRTIQH PFKNIMRRKY RPQLVMAVAI PFFQQVTGIN
     VIAFYAPILF RTIGLEESAS LLSSIVTGLV GSASTFISML IVDKLGRRAL FIFGGVQMFV
     AQIMVGSIMA AELGDHGGIG KGYAYIVLIL ICIYVAGFGW SWGPLGWLVP SEIFPLEIRS
     AGQSIVVAVS FLFTFVVAQT FLSMLCHFKS GIFFFFGGWV VVMTAFVHFL LPETKKVPIE
     KMDIVWRDHW FWKKIIGEEA AEENNKMEAA