ID   ANM7_CULQU              Reviewed;         704 AA.
AC   B0X4N1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Protein arginine N-methyltransferase 7;
DE            EC=2.1.1.-;
GN   Name=Art7; ORFNames=CPIJ014415;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential arginine methyltransferase that can both catalyze
CC       the formation of omega-N monomethylarginine (MMA) and symmetrical
CC       dimethylarginine (sDMA). Specifically mediates the symmetrical
CC       dimethylation of arginine residues in the small nuclear
CC       ribonucleoproteins SmD1 and SmD3 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Protein arginine N-methyltransferase family. PRMT7
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01015}.
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DR   EMBL; DS232348; EDS40448.1; -; Genomic_DNA.
DR   RefSeq; XP_001864603.1; XM_001864568.1.
DR   AlphaFoldDB; B0X4N1; -.
DR   SMR; B0X4N1; -.
DR   STRING; 7176.CPIJ014415-PA; -.
DR   GeneID; 6047555; -.
DR   KEGG; cqu:CpipJ_CPIJ014415; -.
DR   VEuPathDB; VectorBase:CPIJ014415; -.
DR   VEuPathDB; VectorBase:CQUJHB017503; -.
DR   eggNOG; KOG1501; Eukaryota.
DR   HOGENOM; CLU_015180_0_0_1; -.
DR   InParanoid; B0X4N1; -.
DR   OMA; LPMANCA; -.
DR   OrthoDB; 408622at2759; -.
DR   PhylomeDB; B0X4N1; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0018216; P:peptidyl-arginine methylation; ISS:UniProtKB.
DR   GO; GO:0035247; P:peptidyl-arginine omega-N-methylation; IEA:UniProt.
DR   Gene3D; 3.40.50.150; -; 2.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR014644; MeTrfase_PRMT7.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PTHR11006; 1.
DR   PIRSF; PIRSF036946; Arg_N-mtase; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   PROSITE; PS51678; SAM_MT_PRMT; 2.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..704
FT                   /note="Protein arginine N-methyltransferase 7"
FT                   /id="PRO_0000373910"
FT   DOMAIN          30..377
FT                   /note="SAM-dependent MTase PRMT-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT   DOMAIN          380..704
FT                   /note="SAM-dependent MTase PRMT-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT   REGION          642..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        643..657
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  78347 MW;  E57ECFE754CFC86C CRC64;
     MMTKPNQRGG RQKSDTQNNL VLNCKMKMYD DAGSDSDDGF DLRQEIARSA FADMCHDWER
     NQKYDQALQL TIGRLHAAGR EAHVLDIGTG SGLLSMMAVR AGADSVVACE AFRPMADCAE
     RVMAANGFGA DRIRLIKKRS TEVRVGPGLD MERKANVLVT ELFDTELIGE GAIATYRHAL
     EHLLEPGCLT IPHSATVYAQ LVECPLAVSW QVPKILGNAD GDVLLRTPED VVDCRGSSAV
     FDVQLSQLPE TSFNALSEPV SVFGFEWSNR EELEVKRHSK KPVEIIRGGI PQAVFMWWDL
     KMDLEGSVLL SCAPFWAHPD FSSLKESNKN PTIPEQNLIP WRDHWMQAIY FLPYTKNTLI
     PGQRVNLDSF HDEFSLWFGL ESPNLPPTHC SCGFHIAYSR SRIGQLNDGL RNKRSLNYLE
     QILDKSSTVL VIGDGSLLGV AIGALGVSHV YLLEPGQLSR TCMESYIRFN GLKNVSILSD
     LAELDASQRA AISHVYGEPY FGSAILPWEN AIQFGALVKQ IRPVLPPKVT FIPHSFSVHA
     VPVEFLDLHK INAPLGTCEG FDLSAMDRMI EEHSNETDSP VEAQPLWEYP SFALGTPSKL
     LSLPLSQDLP ETQLWQGEFQ LTQNPEKCNG IAVWADWHMD GSGSPKTTIS TGPLESTADG
     EQPIRWNANW RQGVHLVKKA PRDGVVKWSV KFNGQLRACY FQFE