ID   HEXA_STRPN              Reviewed;         844 AA.
AC   P0A3R3; P10564;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein HexA;
GN   Name=hexA; OrderedLocusNames=SP_2076;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=175;
RX   PubMed=3275608; DOI=10.1128/jb.170.1.190-196.1988;
RA   Priebe S.D., Hadi S.M., Greenberg B., Lacks S.A.;
RT   "Nucleotide sequence of the hexA gene for DNA mismatch repair in
RT   Streptococcus pneumoniae and homology of hexA to mutS of Escherichia coli
RT   and Salmonella typhimurium.";
RL   J. Bacteriol. 170:190-196(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AE005672; Type=Frameshift; Note=This may be a natural frameshift.; Evidence={ECO:0000305};
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DR   EMBL; M18729; AAA88597.1; -; Genomic_DNA.
DR   EMBL; AE005672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; C28667; C28667.
DR   RefSeq; WP_000963680.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A3R3; -.
DR   SMR; P0A3R3; -.
DR   GeneID; 60232608; -.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; P0A3R3; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..844
FT                   /note="DNA mismatch repair protein HexA"
FT                   /id="PRO_0000115147"
FT   BINDING         602..609
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   844 AA;  94848 MW;  59C1B963D90B6EE2 CRC64;
     MAIEKLSPGM QQYVDIKKQY PDAFLLFRMG DFYELFYEDA VNAAQILEIS LTSRNKNADN
     PIPMAGVPYH SAQQYIDVLI EQGYKVAIAE QMEDPKQAVG VVKREVVQVI TPGTVVDSSK
     PDSQNNFLVS IDREGNQFGL AYMDLVTGDF YVTGLLDFTL VCGEIRNLKA REVVLGYDLS
     EEEEQILSRQ MNLVLSYEKE SFEDLHLLDL RLATVEQTAS SKLLQYVHRT QMRELNHLKP
     VIRYEIKDFL QMDYATKASL DLVENARSGK KQGSLFWLLD ETKTAMGMRL LRSWIHRPLI
     DKERIVQRQE VVQVFLDHFF ERSDLTDSLK GVYDIERLAS RVSFGKTNPK DLLQLATTLS
     SVPRIRAILE GMEQPTLAYL IAQLDAIPEL ESLISAAIAP EAPHVITDGG IIRTGFDETL
     DKYRCVLREG TSWIAEIEAK ERENSGISTL KIDYNKKDGY YFHVTNSQLG NVPAHFFRKA
     TLKNSERFGT EELARIEGDM LEAREKSANL EYEIFMRIRE EVGKYIQRLQ ALAQGIATVD
     VLQSLAVVAE TQHLIRPEFG DDSQIDIRKG RHAVVEKVMG AQTYIPNTIQ MAEDTSIQLV
     TGPNMSGKST YMRQLAMTAV MAQLGSYVPA ESAHLPIFDA IFTRIGAADD LVSGQSTFMV
     EMMEANNAIS HATKNSLILF DELGRGTATY DGMALAQSII EYIHEHIGAK TLFATHYHEL
     TSLESSLQHL VNVHVATLEQ DGQVTFLHKI EPGPADKSYG IHVAKIAGLP ADLLARADKI
     LTQLENQGTE SPPPMRQTSA VTEQISLFDR AEEHPILAEL AKLDVYNMTP MQVMNVLVEL
     KQKL