HEXB_STRPN
ID HEXB_STRPN Reviewed; 649 AA.
AC P0A3R1; P14160; Q9R326; Q9R3V1; Q9Z4T8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=DNA mismatch repair protein HexB;
GN Name=hexB; OrderedLocusNames=SP_0173;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R6 / R800;
RX PubMed=2676973; DOI=10.1128/jb.171.10.5332-5338.1989;
RA Prudhomme M., Martin B., Mejean V., Claverys J.-P.;
RT "Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair
RT gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of
RT Saccharomyces cerevisiae.";
RL J. Bacteriol. 171:5332-5338(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-156 AND 498-614.
RC STRAIN=1011, 1012, 497, 501, 873, 912, E226, KD12, SP8, and SP9;
RX PubMed=10338480; DOI=10.1128/iai.67.6.2776-2782.1999;
RA Whatmore A.M., King S.J., Doherty N.C., Sturgeon D., Chanter N.,
RA Dowson C.G.;
RT "Molecular characterization of equine isolates of Streptococcus pneumoniae:
RT natural disruption of genes encoding the virulence factors pneumolysin and
RT autolysin.";
RL Infect. Immun. 67:2776-2782(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 498-614.
RX PubMed=10678950; DOI=10.1128/iai.68.3.1374-1382.2000;
RA Whatmore A.M., Efstratiou A., Pickerill A.P., Broughton K., Woodard G.,
RA Sturgeon D., George R., Dowson C.G.;
RT "Genetic relationships between clinical isolates of Streptococcus
RT pneumoniae, Streptococcus oralis, and Streptococcus mitis: characterization
RT of 'atypical' pneumococci and organisms allied to S. mitis harboring S.
RT pneumoniae virulence factor-encoding genes.";
RL Infect. Immun. 68:1374-1382(2000).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC The hex system is nick-directed.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000305}.
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DR EMBL; M29686; AAA88600.1; -; Genomic_DNA.
DR EMBL; AE005672; AAK74354.1; -; Genomic_DNA.
DR EMBL; AJ240649; CAB39254.1; -; Genomic_DNA.
DR EMBL; AJ240650; CAB39255.1; -; Genomic_DNA.
DR EMBL; AJ240651; CAB39256.1; -; Genomic_DNA.
DR EMBL; AJ240652; CAB39257.1; -; Genomic_DNA.
DR EMBL; AJ240653; CAB39258.1; -; Genomic_DNA.
DR EMBL; AJ240654; CAB39259.1; -; Genomic_DNA.
DR EMBL; AJ240655; CAB39260.1; -; Genomic_DNA.
DR EMBL; AJ240656; CAB39261.1; -; Genomic_DNA.
DR EMBL; AJ240657; CAB39262.1; -; Genomic_DNA.
DR EMBL; AJ240658; CAB39263.1; -; Genomic_DNA.
DR EMBL; AJ240659; CAB39264.1; -; Genomic_DNA.
DR EMBL; AJ240660; CAB39265.1; -; Genomic_DNA.
DR EMBL; AJ240661; CAB39266.1; -; Genomic_DNA.
DR EMBL; AJ240662; CAB39267.1; -; Genomic_DNA.
DR EMBL; AJ240663; CAB39268.1; -; Genomic_DNA.
DR EMBL; AJ240664; CAB39269.1; -; Genomic_DNA.
DR EMBL; AJ240665; CAB39270.1; -; Genomic_DNA.
DR EMBL; AJ240666; CAB39271.1; -; Genomic_DNA.
DR EMBL; AJ240667; CAB39272.1; -; Genomic_DNA.
DR EMBL; AJ240668; CAB39273.1; -; Genomic_DNA.
DR EMBL; AJ240669; CAB39274.1; -; Genomic_DNA.
DR EMBL; AJ240670; CAB39275.1; -; Genomic_DNA.
DR EMBL; AJ390899; CAB71683.1; -; Genomic_DNA.
DR EMBL; AJ390916; CAB71684.1; -; Genomic_DNA.
DR EMBL; AJ390917; CAB71685.1; -; Genomic_DNA.
DR EMBL; AJ390918; CAB71686.1; -; Genomic_DNA.
DR EMBL; AJ390919; CAB71687.1; -; Genomic_DNA.
DR EMBL; AJ390921; CAB71688.1; -; Genomic_DNA.
DR EMBL; AJ390926; CAB71689.1; -; Genomic_DNA.
DR EMBL; AJ390927; CAB71690.1; -; Genomic_DNA.
DR EMBL; AJ390928; CAB71691.1; -; Genomic_DNA.
DR EMBL; AJ390929; CAB71692.3; ALT_SEQ; Genomic_DNA.
DR EMBL; AJ390930; CAB71693.1; -; Genomic_DNA.
DR EMBL; AJ390931; CAB71694.1; -; Genomic_DNA.
DR PIR; A33589; A33589.
DR PIR; A95020; A95020.
DR RefSeq; WP_000018169.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P0A3R1; -.
DR SMR; P0A3R1; -.
DR STRING; 170187.SP_0173; -.
DR EnsemblBacteria; AAK74354; AAK74354; SP_0173.
DR GeneID; 60232517; -.
DR KEGG; spn:SP_0173; -.
DR eggNOG; COG0323; Bacteria.
DR OMA; AHERIMY; -.
DR PhylomeDB; P0A3R1; -.
DR BioCyc; SPNE170187:G1FZB-182-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..649
FT /note="DNA mismatch repair protein HexB"
FT /id="PRO_0000177977"
FT VARIANT 62
FT /note="H -> Y (in strain: 951)"
FT CONFLICT 28
FT /note="V -> C (in Ref. 1; AAA88600)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 649 AA; 73435 MW; 465C89A3CA7C7E65 CRC64;
MSHIIELPEM LANQIAAGEV IERPASVVKE LVENAIDAGS SQIIIEIEEA GLKKVQITDN
GHGIAHDEVE LALRRHATSK IKNQADLFRI RTLGFRGEAL PSIASVSVLT LLTAVDGASH
GTKLVARGGE VEEVIPATSP VGTKVCVEDL FFNTPARLKY MKSQQAELSH IIDIVNRLGL
AHPEISFSLI SDGKEMTRTA GTGQLRQAIA GIYGLVSAKK MIEIENSDLD FEISGFVSLP
ELTRANRNYI SLFINGRYIK NFLLNRAILD GFGSKLMVGR FPLAVIHIHI DPYLADVNVH
PTKQEVRISK EKELMTLVSE AIANSLKEQT LIPDALENLA KSTVRNREKV EQTILPLKEN
TLYYEKTEPS RPSQTEVADY QVELTDEGQD LTLFAKETLD RLTKPAKLHF AERKPANYDQ
LDHPELDLAS IDKAYDKLER EEASSFPELE FFGQMHGTYL FAQGRDGLYI IDQHAAQERV
KYEEYRESIG NVDQSQQQLL VPYIFEFPAD DALRLKERMP LLEEVGVFLA EYGENQFILR
EHPIWMAEEE IESGIYEMCD MLLLTKEVSI KKYRAELAIM MSCKRSIKAN HRIDDHSARQ
LLYQLSQCDN PYNCPHGRPV LVHFTKSDME KMFRRIQENH TSLRELGKY
