ID   HEXB_STRR6              Reviewed;         649 AA.
AC   P0A3R2; P14160; Q9R326; Q9R3V1; Q9Z4T8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=DNA mismatch repair protein HexB;
GN   Name=hexB; OrderedLocusNames=spr0160;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-156 AND 498-614.
RX   PubMed=10338480; DOI=10.1128/iai.67.6.2776-2782.1999;
RA   Whatmore A.M., King S.J., Doherty N.C., Sturgeon D., Chanter N.,
RA   Dowson C.G.;
RT   "Molecular characterization of equine isolates of Streptococcus pneumoniae:
RT   natural disruption of genes encoding the virulence factors pneumolysin and
RT   autolysin.";
RL   Infect. Immun. 67:2776-2782(1999).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       The hex system is nick-directed.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; AE007317; AAK98964.1; -; Genomic_DNA.
DR   EMBL; AJ240647; CAB39252.1; -; Genomic_DNA.
DR   EMBL; AJ240648; CAB39253.1; -; Genomic_DNA.
DR   PIR; H97891; H97891.
DR   RefSeq; NP_357754.1; NC_003098.1.
DR   RefSeq; WP_000018169.1; NC_003098.1.
DR   AlphaFoldDB; P0A3R2; -.
DR   SMR; P0A3R2; -.
DR   STRING; 171101.spr0160; -.
DR   EnsemblBacteria; AAK98964; AAK98964; spr0160.
DR   GeneID; 60232517; -.
DR   KEGG; spr:spr0160; -.
DR   PATRIC; fig|171101.6.peg.189; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..649
FT                   /note="DNA mismatch repair protein HexB"
FT                   /id="PRO_0000177978"
SQ   SEQUENCE   649 AA;  73435 MW;  465C89A3CA7C7E65 CRC64;
     MSHIIELPEM LANQIAAGEV IERPASVVKE LVENAIDAGS SQIIIEIEEA GLKKVQITDN
     GHGIAHDEVE LALRRHATSK IKNQADLFRI RTLGFRGEAL PSIASVSVLT LLTAVDGASH
     GTKLVARGGE VEEVIPATSP VGTKVCVEDL FFNTPARLKY MKSQQAELSH IIDIVNRLGL
     AHPEISFSLI SDGKEMTRTA GTGQLRQAIA GIYGLVSAKK MIEIENSDLD FEISGFVSLP
     ELTRANRNYI SLFINGRYIK NFLLNRAILD GFGSKLMVGR FPLAVIHIHI DPYLADVNVH
     PTKQEVRISK EKELMTLVSE AIANSLKEQT LIPDALENLA KSTVRNREKV EQTILPLKEN
     TLYYEKTEPS RPSQTEVADY QVELTDEGQD LTLFAKETLD RLTKPAKLHF AERKPANYDQ
     LDHPELDLAS IDKAYDKLER EEASSFPELE FFGQMHGTYL FAQGRDGLYI IDQHAAQERV
     KYEEYRESIG NVDQSQQQLL VPYIFEFPAD DALRLKERMP LLEEVGVFLA EYGENQFILR
     EHPIWMAEEE IESGIYEMCD MLLLTKEVSI KKYRAELAIM MSCKRSIKAN HRIDDHSARQ
     LLYQLSQCDN PYNCPHGRPV LVHFTKSDME KMFRRIQENH TSLRELGKY