ID   HEXI1_XENLA             Reviewed;         285 AA.
AC   Q4V7W3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Protein HEXIM1;
GN   Name=hexim1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator which functions as a general RNA
CC       polymerase II transcription inhibitor. Core component of the 7SK RNP
CC       complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large
CC       inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation
CC       and subsequent transcriptional elongation. Plays a role in the
CC       regulation of DNA virus-mediated innate immune response by assembling
CC       into the HDP-RNP complex, a complex that serves as a platform for IRF3
CC       phosphorylation and subsequent innate immune response activation
CC       through the cGAS-STING pathway. {ECO:0000250|UniProtKB:O94992}.
CC   -!- SUBUNIT: Homooligomer and heterooligomer. Core component of the 7SK RNP
CC       complex. {ECO:0000250|UniProtKB:O94992}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94992}. Cytoplasm
CC       {ECO:0000250|UniProtKB:O94992}. Note=Binds alpha-importin and is mostly
CC       nuclear. {ECO:0000250|UniProtKB:O94992}.
CC   -!- SIMILARITY: Belongs to the HEXIM family. {ECO:0000305}.
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DR   EMBL; BC097693; AAH97693.1; -; mRNA.
DR   RefSeq; NP_001090038.1; NM_001096569.1.
DR   AlphaFoldDB; Q4V7W3; -.
DR   SMR; Q4V7W3; -.
DR   PRIDE; Q4V7W3; -.
DR   DNASU; 735111; -.
DR   GeneID; 735111; -.
DR   KEGG; xla:735111; -.
DR   CTD; 735111; -.
DR   Xenbase; XB-GENE-987000; hexim1.L.
DR   OMA; YCEPERT; -.
DR   OrthoDB; 1564974at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 735111; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR   GO; GO:0017069; F:snRNA binding; IEA:InterPro.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR024872; HEXIM.
DR   PANTHER; PTHR13469; PTHR13469; 1.
DR   Pfam; PF15313; HEXIM; 1.
DR   PRINTS; PR02094; HEXIMFAMILY.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..285
FT                   /note="Protein HEXIM1"
FT                   /id="PRO_0000305270"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          213..284
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        24..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..184
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32488 MW;  78C2240E33E2B455 CRC64;
     MSEVGICKSL AGGGSLLAPK EGGGWHHPVE REEHPVGDAN TVSEGHDKES AYQNPGQLVK
     AEAQEDDWKE LGKKRHRRLR SKNKRRWKPY DKLTWEEKKE LEERQSQRAS RIRAEMIAKG
     QPVAPYNTTQ FLMEDHDQEE PDLCPPPRKS SAALPLALNN SSYKGDSTDD DLEEEEDEAG
     SDGMGGYDGE DFLQKDFSET YERYHAESLQ DMSKQDLIKE YLELEKCLSR MEEENNHLRV
     QSLASAPAAD HRDTRIQELQ VELEKLKEEN QRLLQEGKQV AADSP