ID   HEXP_LEIMA              Reviewed;         271 AA.
AC   Q04832;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=DNA-binding protein HEXBP;
DE   AltName: Full=Hexamer-binding protein;
GN   Name=HEXBP;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NIH S;
RX   PubMed=8314766; DOI=10.1016/s0021-9258(19)85200-6;
RA   Webb J.R., McMaster W.R.;
RT   "Molecular cloning and expression of a Leishmania major gene encoding a
RT   single-stranded DNA-binding protein containing nine 'CCHC' zinc finger
RT   motifs.";
RL   J. Biol. Chem. 268:13994-14002(1993).
CC   -!- FUNCTION: Binds to single-stranded DNA located in the 5' hexanucleotide
CC       repeat region of the L.major leishmanolysin (GP63) gene.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M94390; AAA29245.1; -; Genomic_DNA.
DR   PIR; A47156; A47156.
DR   AlphaFoldDB; Q04832; -.
DR   SMR; Q04832; -.
DR   STRING; 5664.LmjF.36.1640; -.
DR   VEuPathDB; TriTrypDB:LmjF.36.1640; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_360022900; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_360022700; -.
DR   eggNOG; KOG3070; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   Pfam; PF00098; zf-CCHC; 9.
DR   SMART; SM00343; ZnF_C2HC; 9.
DR   SUPFAM; SSF57756; SSF57756; 5.
DR   PROSITE; PS50158; ZF_CCHC; 9.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..271
FT                   /note="DNA-binding protein HEXBP"
FT                   /id="PRO_0000083955"
FT   ZN_FING         16..33
FT                   /note="CCHC-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         43..60
FT                   /note="CCHC-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         70..87
FT                   /note="CCHC-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         97..114
FT                   /note="CCHC-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         140..157
FT                   /note="CCHC-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         168..185
FT                   /note="CCHC-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         196..213
FT                   /note="CCHC-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         222..239
FT                   /note="CCHC-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   ZN_FING         253..270
FT                   /note="CCHC-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  28226 MW;  1D33892EF9F743D8 CRC64;
     MSETEDVKRP RTESSTSCRN CGKEGHYARE CPEADSKGDE RSTTCFRCGE EGHMSRECPN
     EARSGAAGAM TCFRCGEAGH MSRDCPNSAK PGAAKGFECY KCGQEGHLSR DCPSSQGGSR
     GGYGQKRGRS GAQGGYSGDR TCYKCGDAGH ISRDCPNGQG GYSGAGDRTC YKCGDAGHIS
     RDCPNGQGGY SGAGDRKCYK CGESGHMSRE CPSAGSTGSG DRACYKCGKP GHISRECPEA
     GGSYGGSRGG GDRTCYKCGE AGHISRDCPS S