HEXR_ECOLI
ID HEXR_ECOLI Reviewed; 289 AA.
AC P46118; P76282;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=HTH-type transcriptional regulator HexR;
DE AltName: Full=Hex regulon repressor;
GN Name=hexR; Synonyms=yebK; OrderedLocusNames=b1853, JW1842;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-123.
RC STRAIN=K12;
RX PubMed=1704005; DOI=10.1128/jb.173.3.968-977.1991;
RA Rowley D.L., Wolf R.E. Jr.;
RT "Molecular characterization of the Escherichia coli K-12 zwf gene encoding
RT glucose 6-phosphate dehydrogenase.";
RL J. Bacteriol. 173:968-977(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-289.
RC STRAIN=K12 / EMG2;
RA Estep P., O'Keeffe T., Robison K., Church G.M.;
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION.
RX PubMed=7567469; DOI=10.1093/nar/23.17.3554;
RA Borodovsky M., McIninch J., Koonin E.V., Rudd K.E., Medigue C., Danchin A.;
RT "Detection of new genes in a bacterial genome using Markov models for three
RT gene classes.";
RL Nucleic Acids Res. 23:3554-3562(1995).
CC -!- FUNCTION: Represses the expression of the hex regulon (zwf, eda, glp
CC and gap). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=M55005; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U00096; AAC74923.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15661.1; -; Genomic_DNA.
DR EMBL; M55005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U27210; AAA68942.1; -; Genomic_DNA.
DR PIR; E64947; E64947.
DR RefSeq; NP_416367.1; NC_000913.3.
DR RefSeq; WP_001056706.1; NZ_SSZK01000001.1.
DR AlphaFoldDB; P46118; -.
DR SMR; P46118; -.
DR BioGRID; 4260935; 14.
DR DIP; DIP-9891N; -.
DR IntAct; P46118; 2.
DR STRING; 511145.b1853; -.
DR jPOST; P46118; -.
DR PaxDb; P46118; -.
DR PRIDE; P46118; -.
DR EnsemblBacteria; AAC74923; AAC74923; b1853.
DR EnsemblBacteria; BAA15661; BAA15661; BAA15661.
DR GeneID; 66674257; -.
DR GeneID; 946373; -.
DR KEGG; ecj:JW1842; -.
DR KEGG; eco:b1853; -.
DR PATRIC; fig|1411691.4.peg.395; -.
DR EchoBASE; EB2702; -.
DR eggNOG; COG1737; Bacteria.
DR HOGENOM; CLU_055769_0_0_6; -.
DR InParanoid; P46118; -.
DR OMA; VPFIHRS; -.
DR PhylomeDB; P46118; -.
DR BioCyc; EcoCyc:EG12860-MON; -.
DR PRO; PR:P46118; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF53697; SSF53697; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..289
FT /note="HTH-type transcriptional regulator HexR"
FT /id="PRO_0000068623"
FT DOMAIN 1..77
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT DOMAIN 121..260
FT /note="SIS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT CONFLICT 82
FT /note="N -> Y (in Ref. 5; AAA68942)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 289 AA; 31976 MW; 34F43A9C6FC89EFF CRC64;
MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT VNRFCRSMDT
RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE SAMATLDHVR HSLDKSAINR
AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV
LISHTGRTKN LVELAQLARE NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR
LAQLTVIDVL ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR
