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HEXR_PSEAE
ID   HEXR_PSEAE              Reviewed;         285 AA.
AC   O68281; Q9HZ53;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=HTH-type transcriptional regulator HexR {ECO:0000305};
DE   AltName: Full=Hex regulon repressor {ECO:0000312|EMBL:AAC38310.1};
GN   Name=hexR {ECO:0000312|EMBL:AAC38310.1};
GN   OrderedLocusNames=PA3184 {ECO:0000312|EMBL:AAG06572.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RA   Hager P.W., Dail M.B., Phibbs P.V. Jr.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Involved in regulation of glucose metabolism. Transcriptional
CC       repressor of the gap-1 gene and of the edd-glk-gltR-2 and zwf-pgl-eda
CC       operons. Acts by binding directly to an inverted pseudopalindromic
CC       sequence in the promoter region. {ECO:0000250|UniProtKB:Q88P32}.
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DR   EMBL; AF029673; AAC38310.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06572.1; -; Genomic_DNA.
DR   PIR; B83248; B83248.
DR   RefSeq; NP_251874.1; NC_002516.2.
DR   RefSeq; WP_003091466.1; NZ_QZGE01000023.1.
DR   AlphaFoldDB; O68281; -.
DR   SMR; O68281; -.
DR   STRING; 287.DR97_4752; -.
DR   PaxDb; O68281; -.
DR   PRIDE; O68281; -.
DR   EnsemblBacteria; AAG06572; AAG06572; PA3184.
DR   GeneID; 882618; -.
DR   KEGG; pae:PA3184; -.
DR   PATRIC; fig|208964.12.peg.3328; -.
DR   PseudoCAP; PA3184; -.
DR   HOGENOM; CLU_055769_0_0_6; -.
DR   InParanoid; O68281; -.
DR   OMA; VPFIHRS; -.
DR   PhylomeDB; O68281; -.
DR   BioCyc; PAER208964:G1FZ6-3244-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd05013; SIS_RpiR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR000281; HTH_RpiR.
DR   InterPro; IPR035472; RpiR-like_SIS.
DR   InterPro; IPR001347; SIS_dom.
DR   InterPro; IPR046348; SIS_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF01418; HTH_6; 1.
DR   Pfam; PF01380; SIS; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF53697; SSF53697; 1.
DR   PROSITE; PS51071; HTH_RPIR; 1.
DR   PROSITE; PS51464; SIS; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..285
FT                   /note="HTH-type transcriptional regulator HexR"
FT                   /id="PRO_0000068624"
FT   DOMAIN          2..78
FT                   /note="HTH rpiR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT   DOMAIN          122..261
FT                   /note="SIS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT   CONFLICT        104
FT                   /note="I -> F (in Ref. 1; AAC38310)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   285 AA;  31170 MW;  0EF1A86101F2C7BC CRC64;
     MKNLLEQIQS RLDELNKAER KVAEVILQNP QQATRFSIAA LAQAAAVSEP TVNRFCRSFG
     MSGYPELKIQ LAQSLASGAA FVTQAVAEDD GPEAYTRKIF SNTIASLDSA HKLLDPRVID
     RAVDLLIQAR QIHFFGLGAS ASVALDAQHK FFRFNLAVSA QADVLMQRMI ASVAHTGDLF
     VVISYTGRTR ELVEVAHLAR ENGASVLGLT AAGSPLARAS TLCLDIPLPE DTDIYMPMTS
     RIVQLTVLDV LATGVTLRRG VDFQPHLRRI KESLVPTRYP LDEDN
 
 
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