HEY1_BOVIN
ID HEY1_BOVIN Reviewed; 304 AA.
AC Q2KIN4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 1;
GN Name=HEY1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor which binds preferentially to the
CC canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch
CC signaling required for cardiovascular development. Specifically
CC required for the Notch-induced endocardial epithelial to mesenchymal
CC transition, which is itself criticial for cardiac valve and septum
CC development. May be required in conjunction with HEY2 to specify
CC arterial cell fate or identity. Promotes maintenance of neuronal
CC precursor cells and glial versus neuronal fate specification. Represses
CC transcription by the cardiac transcriptional activators GATA4 and GATA6
CC and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
CC {ECO:0000250|UniProtKB:Q9WV93, ECO:0000250|UniProtKB:Q9Y5J3}.
CC -!- SUBUNIT: Self-associates. Interacts with HES1 and HEYL. Interacts with
CC HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with
CC CCDC89/BOIP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000305}.
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DR EMBL; BC112574; AAI12575.1; -; mRNA.
DR RefSeq; NP_001001172.2; NM_001001172.3.
DR AlphaFoldDB; Q2KIN4; -.
DR SMR; Q2KIN4; -.
DR STRING; 9913.ENSBTAP00000020864; -.
DR PaxDb; Q2KIN4; -.
DR Ensembl; ENSBTAT00000020864; ENSBTAP00000020864; ENSBTAG00000015717.
DR GeneID; 408005; -.
DR KEGG; bta:408005; -.
DR CTD; 23462; -.
DR VEuPathDB; HostDB:ENSBTAG00000015717; -.
DR VGNC; VGNC:29828; HEY1.
DR eggNOG; KOG4304; Eukaryota.
DR GeneTree; ENSGT00940000157068; -.
DR HOGENOM; CLU_048294_2_0_1; -.
DR InParanoid; Q2KIN4; -.
DR OMA; EPHHQSR; -.
DR OrthoDB; 1201152at2759; -.
DR TreeFam; TF323617; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000015717; Expressed in floor plate of diencephalon and 102 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0072359; P:circulatory system development; IBA:GO_Central.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:2000820; P:negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Notch signaling pathway; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..304
FT /note="Hairy/enhancer-of-split related with YRPW motif
FT protein 1"
FT /id="PRO_0000269176"
FT DOMAIN 49..104
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 122..158
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..117
FT /note="Transcriptional repression and interaction with
FT NCOR1 and SIN3A"
FT /evidence="ECO:0000250"
FT REGION 197..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 294..297
FT /note="YRPW motif"
FT COMPBIAS 28..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 304 AA; 32572 MW; 0D1DDF3D0F8E2D3B CRC64;
MKRAHPEYSS SESELDETIE VEKESADENG NLSSALGSMS PTTSSQILAR KRRRGIIEKR
RRDRINNSLS ELRRLVPSAF EKQGSAKLEK AEILQMTVDH LKMLHTAGGK GYFDAHALAM
DYRSLGFREC LAEVARYLSI IEGLDASDPL RVRLVSHLNN YASQREAASG AHAGLGHIPW
GSAFGHHPHV AHPLLLSQST HGNTGTSASP TESHHQGRLA TAHPEASALR APPSGGLGPV
LPVVTSASKL SPPLLSSVAS LSAFPFSFGS FHLLSPNALS PSAPTQAANL GKPYRPWGTE
IGAF
