ID   ANM7_DROMO              Reviewed;         698 AA.
AC   B4KSL6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Protein arginine N-methyltransferase 7;
DE            EC=2.1.1.-;
GN   Name=Art7; ORFNames=GI21139;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Essential arginine methyltransferase that can both catalyze
CC       the formation of omega-N monomethylarginine (MMA) and symmetrical
CC       dimethylarginine (sDMA). Specifically mediates the symmetrical
CC       dimethylation of arginine residues in the small nuclear
CC       ribonucleoproteins SmD1 and SmD3 (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Protein arginine N-methyltransferase family. PRMT7
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01015}.
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DR   EMBL; CH933808; EDW10515.1; -; Genomic_DNA.
DR   RefSeq; XP_002006580.1; XM_002006544.2.
DR   RefSeq; XP_015019889.1; XM_015164403.1.
DR   RefSeq; XP_015019890.1; XM_015164404.1.
DR   AlphaFoldDB; B4KSL6; -.
DR   SMR; B4KSL6; -.
DR   STRING; 7230.FBpp0170356; -.
DR   EnsemblMetazoa; FBtr0171864; FBpp0170356; FBgn0143871.
DR   EnsemblMetazoa; FBtr0422443; FBpp0380492; FBgn0143871.
DR   EnsemblMetazoa; FBtr0424994; FBpp0382787; FBgn0143871.
DR   GeneID; 6580777; -.
DR   KEGG; dmo:Dmoj_GI21139; -.
DR   eggNOG; KOG1501; Eukaryota.
DR   HOGENOM; CLU_015180_0_0_1; -.
DR   InParanoid; B4KSL6; -.
DR   OMA; LPMANCA; -.
DR   OrthoDB; 408622at2759; -.
DR   PhylomeDB; B4KSL6; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0018216; P:peptidyl-arginine methylation; ISS:UniProtKB.
DR   GO; GO:0035247; P:peptidyl-arginine omega-N-methylation; IEA:UniProt.
DR   Gene3D; 3.40.50.150; -; 2.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR014644; MeTrfase_PRMT7.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PTHR11006; 1.
DR   PIRSF; PIRSF036946; Arg_N-mtase; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   PROSITE; PS51678; SAM_MT_PRMT; 2.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..698
FT                   /note="Protein arginine N-methyltransferase 7"
FT                   /id="PRO_0000373915"
FT   DOMAIN          14..357
FT                   /note="SAM-dependent MTase PRMT-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
FT   DOMAIN          366..698
FT                   /note="SAM-dependent MTase PRMT-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01015"
SQ   SEQUENCE   698 AA;  79180 MW;  ED9F9A3E8C4DA7BA CRC64;
     MASFAQVINP MTGQNTWQER GDDYDYHQEV ANAGFGDMLH DWERNQKYDA AIRKTIAGMR
     QAGKQVHVLD IGTGTGILAM MALRAGADTV TACEAFVPMA NCAARILAAN DAAHVRLIRK
     RSTDIVMGVD MPHRANLLVA ELLDTELIGE GAIGIYNHAH EELLTDDALC IPARATCYAQ
     VAQSPLASQW NSLKILPDLD GDILLRPPTQ LLQCSGEAAL HDVQLSQLPP HSFHVLSEPT
     QIFHFDFQRK QPLELMRENV VRVQLSRPGS VELVFYWWQI ELDDAGEQLL SCAPYWAHPE
     LEQLKATCKD KQRPLANIVP WRDHWMQAIY YIPKALHLHD AGEEFWLRCY HDEYSLWFDA
     HKEQPEKPAR RHSCTCDLHM TYTRNRIGQL NQSIRNKRYL AYLEQAVQSK SAHVLVMGDG
     CLLGLASAAL GAASVYCLEP HRFSRRLLES VVKHNQLKNV KFLDSLKQLE PNELDTITHI
     FAEPYFLNSI LPWDNFYFGT LLLQLEQLHQ KLPANVEISP CAARIFALPV EFLDLHKIRA
     PIVSCEGFDL RLFDDMVQRS AEQALSQVEA QPLWEYPCRA LAQPQQLLSV DFANFGVEQS
     NHGSIKLTAE GNCNGIALWV DWQLSPNENP KSIVSSGPLE PVETGQYVKW DMFVRQGVHF
     INQTTAEKKY LNWSTQFRPL LGELNFNFSL NANREKSE