ID   HEY1_DANRE              Reviewed;         317 AA.
AC   Q8AXV6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 1;
GN   Name=hey1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=14593478; DOI=10.1007/s00427-003-0360-6;
RA   Winkler C., Elmasri H., Klamt B., Volff J.-N., Gessler M.;
RT   "Characterization of hey bHLH genes in teleost fish.";
RL   Dev. Genes Evol. 213:541-553(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor which functions as a downstream
CC       effector of Notch signaling. {ECO:0000250|UniProtKB:Q9WV93}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380,
CC       ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- DEVELOPMENTAL STAGE: Expressed following gastrulation. At the 1-somite
CC       stage, expressed in the paraxial mesoderm. Subsequently expressed in
CC       the telencephalon, the otic vesicles, the somites and the anterior
CC       presomitic mesoderm. {ECO:0000269|PubMed:14593478}.
CC   -!- INDUCTION: Expression in the developing embryo is induced by activation
CC       of the Notch signaling pathway. {ECO:0000269|PubMed:14593478}.
CC   -!- SIMILARITY: Belongs to the HEY family. {ECO:0000305}.
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DR   EMBL; AJ510221; CAD53342.1; -; mRNA.
DR   EMBL; BC095317; AAH95317.1; -; mRNA.
DR   RefSeq; NP_997726.1; NM_212561.1.
DR   AlphaFoldDB; Q8AXV6; -.
DR   SMR; Q8AXV6; -.
DR   STRING; 7955.ENSDARP00000094416; -.
DR   PaxDb; Q8AXV6; -.
DR   Ensembl; ENSDART00000103640; ENSDARP00000094416; ENSDARG00000070538.
DR   GeneID; 58008; -.
DR   KEGG; dre:58008; -.
DR   CTD; 23462; -.
DR   ZFIN; ZDB-GENE-000607-70; hey1.
DR   eggNOG; KOG4304; Eukaryota.
DR   GeneTree; ENSGT00940000157068; -.
DR   HOGENOM; CLU_048294_2_0_1; -.
DR   InParanoid; Q8AXV6; -.
DR   OMA; EPHHQSR; -.
DR   OrthoDB; 1201152at2759; -.
DR   PhylomeDB; Q8AXV6; -.
DR   TreeFam; TF323617; -.
DR   PRO; PR:Q8AXV6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000070538; Expressed in somite and 53 other tissues.
DR   ExpressionAtlas; Q8AXV6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR   GO; GO:0072359; P:circulatory system development; IBA:GO_Central.
DR   GO; GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003650; Orange_dom.
DR   Pfam; PF07527; Hairy_orange; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00511; ORANGE; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS51054; ORANGE; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Notch signaling pathway; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..317
FT                   /note="Hairy/enhancer-of-split related with YRPW motif
FT                   protein 1"
FT                   /id="PRO_0000286425"
FT   DOMAIN          48..103
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   DOMAIN          121..157
FT                   /note="Orange"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           307..310
FT                   /note="YRPW motif"
FT   COMPBIAS        30..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..262
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  33938 MW;  A6838729149D8D24 CRC64;
     MKRNHDFSSS DSELDENIEV EKESADENAG ANSPLGSMSP STTSQVQARK RRRGIIEKRR
     RDRINNSLSE LRRLVPSAFE KQGSAKLEKA EILQMTVDHL KMLHAAGGKG YFDAHALAMD
     YRGLGFRECL AETARYLSII EGLDNTDPLR IRLVSHLNSY ASQREAHSGL GHLAWGSAFG
     TPPSHLAHHL LLQQQQQQGA PLARSTSSPP SSNSSSPSSS SPSAPSTEPR LSGTVISEAG
     QTGPLRVPPS TSLPPGLTPP TASKLSPPLL TSLSSLSAFP FPLSAFPLLS PSSLGPATPS
     SSLGKPYRPW SMEIGAF