HEYL_DANRE
ID HEYL_DANRE Reviewed; 310 AA.
AC Q8AXV5; Q1L9E8;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Hairy/enhancer-of-split related with YRPW motif-like protein;
GN Name=heyl; ORFNames=si:dkey-148n22.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=14593478; DOI=10.1007/s00427-003-0360-6;
RA Winkler C., Elmasri H., Klamt B., Volff J.-N., Gessler M.;
RT "Characterization of hey bHLH genes in teleost fish.";
RL Dev. Genes Evol. 213:541-553(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Transcriptional repressor which functions as a downstream
CC effector of Notch signaling. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- DEVELOPMENTAL STAGE: Expressed at low levels during embryogenesis.
CC Expressed in the ventral fin fold of the forming and extending tailbud
CC and in the ventral regions of the neural tube.
CC {ECO:0000269|PubMed:14593478}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000305}.
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DR EMBL; AJ510222; CAD53343.1; -; mRNA.
DR EMBL; CR318628; CAK05162.1; -; Genomic_DNA.
DR RefSeq; NP_859425.1; NM_181736.1.
DR AlphaFoldDB; Q8AXV5; -.
DR SMR; Q8AXV5; -.
DR STRING; 7955.ENSDARP00000072659; -.
DR PaxDb; Q8AXV5; -.
DR Ensembl; ENSDART00000078197; ENSDARP00000072659; ENSDARG00000055798.
DR Ensembl; ENSDART00000181837; ENSDARP00000151424; ENSDARG00000112770.
DR GeneID; 335134; -.
DR KEGG; dre:335134; -.
DR CTD; 26508; -.
DR ZFIN; ZDB-GENE-030131-7074; heyl.
DR eggNOG; KOG4304; Eukaryota.
DR GeneTree; ENSGT00940000166437; -.
DR HOGENOM; CLU_048294_1_1_1; -.
DR InParanoid; Q8AXV5; -.
DR OMA; FLPCPAW; -.
DR OrthoDB; 1201152at2759; -.
DR PhylomeDB; Q8AXV5; -.
DR TreeFam; TF351373; -.
DR PRO; PR:Q8AXV5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000055798; Expressed in spleen and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Notch signaling pathway; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Hairy/enhancer-of-split related with YRPW motif-like
FT protein"
FT /id="PRO_0000286431"
FT DOMAIN 43..98
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 116..152
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 203
FT /note="A -> T (in Ref. 1; CAD53343)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 33392 MW; 1E85A81B407ACF5F CRC64;
MKRPHDYSSP DSDTDELIDV GQEDSYCPVT GSMSPGSTSQ ILARKKRRGI IEKRRRDRIN
HSLSELRRLV PSAFEKQGSS KLEKAEILQM TVDHLKLLHA MGGKGYFDAR ALAVDYRTLG
FRECVGEVVR YLSSLEGVES SDPIGARLVS HLSHCASELD PLLQSPAALP FPPWPWASFP
QLQAASPPAS STPFPPNARR DLAPHGTATI LGYPSPALRM GSLSTQGTIL NPALTSVRQL
PSVPGHLHRL QQHSPEGRTV PSSSSSSSNS SPPQISFRPF VPAGSPAGGR RALSSSSKSA
QAWGTEIGAF
