HEY_DROME
ID HEY_DROME Reviewed; 425 AA.
AC Q7KM13; Q058S4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein;
GN Name=Hey; Synonyms=Hesr-1; ORFNames=CG11194;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10403790; DOI=10.1006/bbrc.1999.0880;
RA Kokubo H., Lun Y., Johnson R.L.;
RT "Identification and expression of a novel family of bHLH cDNAs related to
RT Drosophila hairy and enhancer of split.";
RL Biochem. Biophys. Res. Commun. 260:459-465(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor which acts as a downstream effector
CC of Notch signaling. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SIMILARITY: Belongs to the HEY family. {ECO:0000305}.
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DR EMBL; AF151523; AAD46771.1; -; mRNA.
DR EMBL; AE013599; AAF59152.2; -; Genomic_DNA.
DR EMBL; BT029144; ABJ17078.1; -; mRNA.
DR RefSeq; NP_523657.1; NM_078933.3.
DR AlphaFoldDB; Q7KM13; -.
DR SMR; Q7KM13; -.
DR BioGRID; 61625; 49.
DR IntAct; Q7KM13; 8.
DR STRING; 7227.FBpp0087945; -.
DR PaxDb; Q7KM13; -.
DR EnsemblMetazoa; FBtr0088869; FBpp0087945; FBgn0027788.
DR GeneID; 35764; -.
DR KEGG; dme:Dmel_CG11194; -.
DR CTD; 100188776; -.
DR FlyBase; FBgn0027788; Hey.
DR VEuPathDB; VectorBase:FBgn0027788; -.
DR eggNOG; KOG4304; Eukaryota.
DR HOGENOM; CLU_048294_0_0_1; -.
DR InParanoid; Q7KM13; -.
DR OMA; QQVPTYI; -.
DR OrthoDB; 1201152at2759; -.
DR PhylomeDB; Q7KM13; -.
DR SignaLink; Q7KM13; -.
DR BioGRID-ORCS; 35764; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 35764; -.
DR PRO; PR:Q7KM13; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0027788; Expressed in presumptive embryonic/larval nervous system and 9 other tissues.
DR Genevisible; Q7KM13; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048664; P:neuron fate determination; IMP:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Notch signaling pathway; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..425
FT /note="Hairy/enhancer-of-split related with YRPW motif
FT protein"
FT /id="PRO_0000286432"
FT DOMAIN 100..155
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 174..210
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 26..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 416..419
FT /note="YRPW motif"
FT COMPBIAS 28..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 322..323
FT /note="Missing (in Ref. 4; ABJ17078)"
FT /evidence="ECO:0000305"
FT CONFLICT 376
FT /note="I -> L (in Ref. 4; ABJ17078)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 46815 MW; 392399908D9666E8 CRC64;
MDHNMHVNAP SLHHWGYAAG PGVVMPGATA TTPQSHWVPP PQSHHSAHSN HSHGHSQGHS
HGIGSLKRTL SESDCDDLYS EESSKEQISP SEPGSCQLMS RKKRRGVIEK KRRDRINSSL
TELKRLVPSA YEKQGSAKLE KAEILQLTVE HLKSLQSKTL DSLSYDPQRV AMDYHIIGFR
ECAAEVARYL VTIEGMDIQD PLRLRLMSHL QYFVQQRELS AKSCASPGGW SPAAPSSSGY
QPNCAAAPYQ SYAAPANPGA YVSSYPTLSA SPSQQAQQLG GRTSVSRTSG SAVTESLPSH
DLHSDSSSQQ QQQQQQQQQQ QQQHQQQQHQ QQQQRTQTTP QPTQQQHYTH DHSAVHSEQQ
VPTYIELTNS NRPAAIGSDS LSYSAAPQYP VSGLPGQDYN NSSVLQYATP NGAKPYRPWG
AEMAY
