HFA2A_ORYSJ
ID HFA2A_ORYSJ Reviewed; 376 AA.
AC Q84MN7; Q0DNN3; Q10D15; Q52MY7;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Heat stress transcription factor A-2a;
DE AltName: Full=Heat shock protein 41;
DE AltName: Full=Heat stress transcription factor 11;
DE Short=OsHsf-11;
DE AltName: Full=Heat stress transcription factor 4;
DE Short=rHsf4;
GN Name=HSFA2A; Synonyms=HSF11, HSF4, RHSP2;
GN OrderedLocusNames=Os03g0745000, LOC_Os03g53340;
GN ORFNames=OsJ_012039, OSJNBb0036F07.17;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Yao Q.-H., Peng R.-H., Xiong A.-S.;
RT "Isolation rice heat shock factor by modified yeast one-hybrid system
RT method.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Li K.G., Yang J.S.;
RT "Oryza sativa heat shock protein 41 mRNA.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [9]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15625403; DOI=10.1007/bf02712120;
RA Baniwal S.K., Bharti K., Chan K.Y., Fauth M., Ganguli A., Kotak S.,
RA Mishra S.K., Nover L., Port M., Scharf K.-D., Tripp J., Weber C.,
RA Zielinski D., von Koskull-Doering P.;
RT "Heat stress response in plants: a complex game with chaperones and more
RT than twenty heat stress transcription factors.";
RL J. Biosci. 29:471-487(2004).
RN [10]
RP GENE FAMILY, NOMENCLATURE, AND DOMAIN AHA.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
RN [11]
RP INDUCTION.
RX PubMed=18064488; DOI=10.1007/s00425-007-0670-4;
RA Yokotani N., Ichikawa T., Kondou Y., Matsui M., Hirochika H., Iwabuchi M.,
RA Oda K.;
RT "Expression of rice heat stress transcription factor OsHsfA2e enhances
RT tolerance to environmental stresses in transgenic Arabidopsis.";
RL Planta 227:957-967(2008).
CC -!- FUNCTION: Transcriptional regulator that specifically binds DNA of heat
CC shock promoter elements (HSE). {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q84MN7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q84MN7-2; Sequence=VSP_035441, VSP_035442;
CC -!- INDUCTION: Not induced by heat stress. {ECO:0000269|PubMed:18064488}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain. AHA motifs are transcriptional activator
CC elements. {ECO:0000269|PubMed:18407058}.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class A subfamily.
CC {ECO:0000305}.
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DR EMBL; AY332465; AAQ01151.1; -; mRNA.
DR EMBL; AY344486; AAQ23058.1; -; mRNA.
DR EMBL; AY998118; AAX97827.1; -; mRNA.
DR EMBL; AC092558; AAP13005.1; -; Genomic_DNA.
DR EMBL; DP000009; ABF98829.1; -; Genomic_DNA.
DR EMBL; DP000009; ABF98831.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF13155.2; -; Genomic_DNA.
DR EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM000140; EAZ28556.1; -; Genomic_DNA.
DR EMBL; AK109590; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015628945.1; XM_015773459.1. [Q84MN7-1]
DR AlphaFoldDB; Q84MN7; -.
DR SMR; Q84MN7; -.
DR IntAct; Q84MN7; 1.
DR MINT; Q84MN7; -.
DR STRING; 4530.OS03T0745000-01; -.
DR PaxDb; Q84MN7; -.
DR PRIDE; Q84MN7; -.
DR GeneID; 4334080; -.
DR KEGG; osa:4334080; -.
DR eggNOG; KOG0627; Eukaryota.
DR InParanoid; Q84MN7; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000007752; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..376
FT /note="Heat stress transcription factor A-2a"
FT /id="PRO_0000350821"
FT REGION 137..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..235
FT /note="Hydrophobic repeat HR-A/B"
FT REGION 296..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 182..229
FT /evidence="ECO:0000255"
FT MOTIF 265..269
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 318..325
FT /note="AHA"
FT MOTIF 366..373
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 153..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_035441"
FT VAR_SEQ 89..115
FT /note="AAVLLPRYFKHSNFSSFVRQLNTYGFR -> MRSPPCSSRATSSTATSPASS
FT ASSTPT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_035442"
SQ SEQUENCE 376 AA; 40848 MW; AA6BE37505D9023A CRC64;
MNPLRVIVKE EELDFAAAAA AAAAGEGSPS SWAVGVMDLP RPMEGLGEAG PPPFLCKTYE
VVDDPGTDTV ISWGFAGNSF VVWDANAFAA VLLPRYFKHS NFSSFVRQLN TYGFRKVDPD
RWEFANEGFL RGKKELLKTI KRRRPPPSSP PSSSSSSSSS QHQQQPAAAC LEVGQFGRDG
VVNRLQRDKS VLIAEVVKLR QEQQTTRAQM QAMEERISAA EQKQQQMTVF LARAMKNPGF
LQMLVDRQAG QHGARNRVLE DALSKKRRRP IEYLLTRNGE TCAAGESAAM LAADGVAEPD
GDTTPRGDGG GGGGGDTESF WMQLLSLGLE EKQREDGVAG GVQESNSGGA DVDNDEEDDD
DDVDVLVQSI YHLSPK
