HFA2C_ORYSJ
ID HFA2C_ORYSJ Reviewed; 358 AA.
AC Q338B0; F4MGV0;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Heat stress transcription factor A-2c;
DE AltName: Full=Heat stress transcription factor 25;
DE Short=OsHsf-25;
DE AltName: Full=Heat stress transcription factor 6;
DE Short=OsHSF6;
DE Short=rHsf6;
GN Name=HSFA2C; Synonyms=HSF25, HSF6;
GN OrderedLocusNames=Os10g0419300, LOC_Os10g28340; ORFNames=OsJ_030304;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND
RP INDUCTION.
RX PubMed=16202242; DOI=10.5483/bmbrep.2005.38.5.602;
RA Liu J.-G., Yao Q.-H., Zhang Z., Peng R.-H., Xiong A.-S., Xu F., Zhu H.;
RT "Isolation and characterization of a cDNA encoding two novel heat-shock
RT factor OsHSF6 and OsHSF12 in Oryza sativa L.";
RL J. Biochem. Mol. Biol. 38:602-608(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15625403; DOI=10.1007/bf02712120;
RA Baniwal S.K., Bharti K., Chan K.Y., Fauth M., Ganguli A., Kotak S.,
RA Mishra S.K., Nover L., Port M., Scharf K.-D., Tripp J., Weber C.,
RA Zielinski D., von Koskull-Doering P.;
RT "Heat stress response in plants: a complex game with chaperones and more
RT than twenty heat stress transcription factors.";
RL J. Biosci. 29:471-487(2004).
RN [9]
RP GENE FAMILY, NOMENCLATURE, AND DOMAIN AHA.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional activator that specifically binds DNA of heat
CC shock promoter elements (HSE). {ECO:0000269|PubMed:16202242}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q338B0; Q338B0: HSFA2C; NbExp=2; IntAct=EBI-7005650, EBI-7005650;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q338B0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q338B0-2; Sequence=VSP_035443, VSP_035444;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and immature seeds.
CC {ECO:0000269|PubMed:16202242}.
CC -!- INDUCTION: By heat stress. {ECO:0000269|PubMed:16202242}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain. AHA motifs are transcriptional activator
CC elements. {ECO:0000269|PubMed:18407058}.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class A subfamily.
CC {ECO:0000305}.
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DR EMBL; AY344488; AAQ23060.1; -; mRNA.
DR EMBL; DP000086; AAP53792.1; -; Genomic_DNA.
DR EMBL; DP000086; ABB47624.1; -; Genomic_DNA.
DR EMBL; DP000086; ABB47626.2; -; Genomic_DNA.
DR EMBL; AP008216; BAF26531.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT10875.1; -; Genomic_DNA.
DR EMBL; CM000147; EAZ16095.1; -; Genomic_DNA.
DR EMBL; AK072391; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q338B0; -.
DR SMR; Q338B0; -.
DR MINT; Q338B0; -.
DR STRING; 4530.OS10T0419300-00; -.
DR PaxDb; Q338B0; -.
DR PRIDE; Q338B0; -.
DR EnsemblPlants; Os10t0419300-01; Os10t0419300-01; Os10g0419300. [Q338B0-1]
DR EnsemblPlants; Os10t0419300-02; Os10t0419300-02; Os10g0419300. [Q338B0-2]
DR Gramene; Os10t0419300-01; Os10t0419300-01; Os10g0419300. [Q338B0-1]
DR Gramene; Os10t0419300-02; Os10t0419300-02; Os10g0419300. [Q338B0-2]
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_1_0_1; -.
DR InParanoid; Q338B0; -.
DR OMA; KLAMHIQ; -.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000007752; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR ExpressionAtlas; Q338B0; baseline and differential.
DR Genevisible; Q338B0; OS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Coiled coil; Cytoplasm; DNA-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Stress response;
KW Transcription; Transcription regulation.
FT CHAIN 1..358
FT /note="Heat stress transcription factor A-2c"
FT /id="PRO_0000350823"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..214
FT /note="Hydrophobic repeat HR-A/B"
FT COILED 156..243
FT /evidence="ECO:0000255"
FT MOTIF 229..243
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 265..274
FT /note="AHA1"
FT MOTIF 315..324
FT /note="AHA2"
FT MOTIF 345..352
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..100
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_035443"
FT VAR_SEQ 101
FT /note="Y -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_035444"
SQ SEQUENCE 358 AA; 40785 MW; A6134CBB55469FC5 CRC64;
MDPAAAGIVK EEMLESQQQQ RQEDGGAAPR PMEGLHEVGP PPFLTKTYDL VEDPATDGVV
SWSRAGNSFV VWDPHVFADL LLPRLFKHNN FSSFVRQLNT YGFRKVDPDR WEFANEGFLR
GQRHLLKTIK RRKPPSNAPP SQQQSLTSCL EVGEFGFEEE IDRLKRDKNI LITEVVKLRQ
EQQATKDHVK AMEDRLRAAE QKQVQMMGFL ARAMRNPEFF QQLAQQKEKR KELEDAISKK
RRRPIDNVPF YDPGETSQTE QLDSPYLFDS GVLNELSEPG IPELENLAVN IQDLGKGKVD
EERQNQTNGQ AELGDDFWAE LLVEDFTGKE EQSELDGKID GIDELAQQLG YLSSTSPK
