HFA6A_ARATH
ID HFA6A_ARATH Reviewed; 282 AA.
AC Q1PDN3; A0MFL9; Q9FG80;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Heat stress transcription factor A-6a;
DE Short=AtHsfA6a;
DE AltName: Full=AtHsf-19;
GN Name=HSFA6A; Synonyms=HSF19; OrderedLocusNames=At5g43840;
GN ORFNames=MQD19.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND DOMAIN AHA.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional activator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain. AHA motif is a transcriptional activator
CC element. {ECO:0000269|PubMed:11599559}.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class A subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28741.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB11313.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB026651; BAB11313.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95016.1; -; Genomic_DNA.
DR EMBL; DQ447035; ABE66218.1; -; mRNA.
DR EMBL; DQ653345; ABK28741.1; ALT_SEQ; mRNA.
DR RefSeq; NP_199197.1; NM_123751.2.
DR AlphaFoldDB; Q1PDN3; -.
DR SMR; Q1PDN3; -.
DR BioGRID; 19656; 7.
DR IntAct; Q1PDN3; 3.
DR STRING; 3702.AT5G43840.1; -.
DR iPTMnet; Q1PDN3; -.
DR PaxDb; Q1PDN3; -.
DR PRIDE; Q1PDN3; -.
DR EnsemblPlants; AT5G43840.1; AT5G43840.1; AT5G43840.
DR GeneID; 834406; -.
DR Gramene; AT5G43840.1; AT5G43840.1; AT5G43840.
DR KEGG; ath:AT5G43840; -.
DR Araport; AT5G43840; -.
DR TAIR; locus:2170832; AT5G43840.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_1_2_1; -.
DR InParanoid; Q1PDN3; -.
DR OMA; DTERWEF; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; Q1PDN3; -.
DR PRO; PR:Q1PDN3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q1PDN3; baseline and differential.
DR Genevisible; Q1PDN3; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Stress response; Transcription; Transcription regulation.
FT CHAIN 1..282
FT /note="Heat stress transcription factor A-6a"
FT /id="PRO_0000270807"
FT DNA_BIND 17..111
FT /evidence="ECO:0000250"
FT REGION 111..177
FT /note="Hydrophobic repeat HR-A/B"
FT MOTIF 175..190
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 261..270
FT /note="AHA"
SQ SEQUENCE 282 AA; 33156 MW; 5B3D3BA597ACA342 CRC64;
MDYNLPIPLE GLKETPPTAF LTKTYNIVED SSTNNIVSWS RDNNSFIVWE PETFALICLP
RCFKHNNFSS FVRQLNTYGF KKIDTERWEF ANEHFLKGER HLLKNIKRRK TSSQTQTQSL
EGEIHELRRD RMALEVELVR LRRKQESVKT YLHLMEEKLK VTEVKQEMMM NFLLKKIKKP
SFLQSLRKRN LQGIKNREQK QEVISSHGVE DNGKFVKAEP EEYGDDIDDQ CGGVFDYGDE
LHIASMEHQG QGEDEIEMDS EGIWKGFVLS EEEMCDLVEH FI
