HFA6B_ARATH
ID HFA6B_ARATH Reviewed; 406 AA.
AC Q9LUH8;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 145.
DE RecName: Full=Heat stress transcription factor A-6b;
DE Short=AtHsfA6b;
DE AltName: Full=AtHsf-07;
GN Name=HSFA6b; Synonyms=HSF07; OrderedLocusNames=At3g22830;
GN ORFNames=MWI23.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND DOMAIN AHA.
RX PubMed=11599559; DOI=10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2;
RA Nover L., Bharti K., Doering P., Mishra S.K., Ganguli A., Scharf K.-D.;
RT "Arabidopsis and the heat stress transcription factor world: how many heat
RT stress transcription factors do we need?";
RL Cell Stress Chaperones 6:177-189(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18407058; DOI=10.1016/s1673-8527(08)60016-8;
RA Guo J., Wu J., Ji Q., Wang C., Luo L., Yuan Y., Wang Y., Wang J.;
RT "Genome-wide analysis of heat shock transcription factor families in rice
RT and Arabidopsis.";
RL J. Genet. Genomics 35:105-118(2008).
CC -!- FUNCTION: Transcriptional activator that specifically binds DNA
CC sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- DOMAIN: The hydrophobic-rich region (HR-A/B) corresponds to the
CC oligomerization domain. AHA motif is a transcriptional activator
CC element. {ECO:0000269|PubMed:11599559}.
CC -!- PTM: Exhibits temperature-dependent phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HSF family. Class A subfamily.
CC {ECO:0000305}.
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DR EMBL; AB022223; BAB01258.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76681.1; -; Genomic_DNA.
DR EMBL; AY045974; AAK76648.1; -; mRNA.
DR EMBL; AY079374; AAL85105.1; -; mRNA.
DR RefSeq; NP_188922.1; NM_113182.2.
DR AlphaFoldDB; Q9LUH8; -.
DR SMR; Q9LUH8; -.
DR STRING; 3702.AT3G22830.1; -.
DR PaxDb; Q9LUH8; -.
DR PRIDE; Q9LUH8; -.
DR ProteomicsDB; 230129; -.
DR EnsemblPlants; AT3G22830.1; AT3G22830.1; AT3G22830.
DR GeneID; 821854; -.
DR Gramene; AT3G22830.1; AT3G22830.1; AT3G22830.
DR KEGG; ath:AT3G22830; -.
DR Araport; AT3G22830; -.
DR TAIR; locus:2094339; AT3G22830.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_030308_1_0_1; -.
DR InParanoid; Q9LUH8; -.
DR OMA; KLAMHIQ; -.
DR OrthoDB; 1154048at2759; -.
DR PhylomeDB; Q9LUH8; -.
DR PRO; PR:Q9LUH8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUH8; baseline and differential.
DR Genevisible; Q9LUH8; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015; PTHR10015; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..406
FT /note="Heat stress transcription factor A-6b"
FT /id="PRO_0000270808"
FT DNA_BIND 59..153
FT /evidence="ECO:0000250"
FT REGION 174..240
FT /note="Hydrophobic repeat HR-A/B"
FT REGION 266..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 253..269
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 367..376
FT /note="AHA"
FT MOTIF 392..399
FT /note="Nuclear export signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 266..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 46736 MW; F2DEE3A82536B698 CRC64;
MDPSFRFIKE EFPAGFSDSP SPPSSSSYLY SSSMAEAAIN DPTTLSYPQP LEGLHESGPP
PFLTKTYDLV EDSRTNHVVS WSKSNNSFIV WDPQAFSVTL LPRFFKHNNF SSFVRQLNTY
GFRKVNPDRW EFANEGFLRG QKHLLKNIRR RKTSNNSNQM QQPQSSEQQS LDNFCIEVGR
YGLDGEMDSL RRDKQVLMME LVRLRQQQQS TKMYLTLIEE KLKKTESKQK QMMSFLARAM
QNPDFIQQLV EQKEKRKEIE EAISKKRQRP IDQGKRNVED YGDESGYGND VAASSSALIG
MSQEYTYGNM SEFEMSELDK LAMHIQGLGD NSSAREEVLN VEKGNDEEEV EDQQQGYHKE
NNEIYGEGFW EDLLNEGQNF DFEGDQENVD VLIQQLGYLG SSSHTN
