ID   HFLC_BUCAP              Reviewed;         307 AA.
AC   Q8K915;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Protein HflC;
GN   Name=hflC; OrderedLocusNames=BUsg_547;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: HflC and HflK could regulate a protease. {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE013218; AAM68086.1; -; Genomic_DNA.
DR   RefSeq; WP_011054052.1; NC_004061.1.
DR   AlphaFoldDB; Q8K915; -.
DR   SMR; Q8K915; -.
DR   STRING; 198804.BUsg_547; -.
DR   MEROPS; I87.001; -.
DR   PRIDE; Q8K915; -.
DR   EnsemblBacteria; AAM68086; AAM68086; BUsg_547.
DR   KEGG; bas:BUsg_547; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_059167_3_0_6; -.
DR   OMA; DFFAFYR; -.
DR   OrthoDB; 1714999at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052547; P:regulation of peptidase activity; IEA:InterPro.
DR   CDD; cd03405; SPFH_HflC; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010200; HflC.
DR   PANTHER; PTHR42911; PTHR42911; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PIRSF; PIRSF005651; HflC; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01932; hflC; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Protein HflC"
FT                   /id="PRO_0000094071"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  35444 MW;  0ED2B7509FF43F34 CRC64;
     MNKIVICILS FFLLIFSSSF FIVKEGERGI ILQFGKVLRN NKQKTLVYTP GLHFKIPFFE
     NVKILDSRIH TMDNQADRFV TKEKKDLIVD SYIKWRISDF SRYYLATGGG DFFQAEVLLK
     RKFSDRLRSE IGRLNVKEIV TDSRGRLTTD VLYSLNKGTI NLDSTSLINV NSMNALGIEV
     VDVRIKQINL PLEVSDAIYN RMRAERESVA RSQRSQGQEK AEKLRATADY RVSLILAEAQ
     KKALMIKGQG EAEVAKLFLE NFGQESSFYF FIRSLHAYEN SFKNSNNIML INSDNEFFKY
     MNTEIKN