ID   HFLC_HAEIN              Reviewed;         295 AA.
AC   P44545;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Protein HflC;
GN   Name=hflC; OrderedLocusNames=HI_0150;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: HflC and HflK could regulate a protease. {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC21821.1; -; Genomic_DNA.
DR   PIR; I64050; I64050.
DR   RefSeq; NP_438320.1; NC_000907.1.
DR   RefSeq; WP_005660876.1; NC_000907.1.
DR   AlphaFoldDB; P44545; -.
DR   SMR; P44545; -.
DR   STRING; 71421.HI_0150; -.
DR   MEROPS; I87.001; -.
DR   EnsemblBacteria; AAC21821; AAC21821; HI_0150.
DR   KEGG; hin:HI_0150; -.
DR   PATRIC; fig|71421.8.peg.153; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_059167_3_0_6; -.
DR   OMA; DFFAFYR; -.
DR   PhylomeDB; P44545; -.
DR   BioCyc; HINF71421:G1GJ1-162-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052547; P:regulation of peptidase activity; IEA:InterPro.
DR   CDD; cd03405; SPFH_HflC; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010200; HflC.
DR   PANTHER; PTHR42911; PTHR42911; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PIRSF; PIRSF005651; HflC; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01932; hflC; 2.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..295
FT                   /note="Protein HflC"
FT                   /id="PRO_0000094076"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   295 AA;  32902 MW;  C5FC24E1ECCF42E3 CRC64;
     MRRFLLPVIF VIAAVVYSSI VVVTEGTRGI MLRFNKVQRD ADNKVVVYEP GLHFKVPLID
     SIKVLDARIR TLDGSATRFV TVEKKDLLVD SYVKWKISDF GRFYTSTGGG DYAQAANLLS
     RKVNDRLRSE IGSRTIKDIV SGTRGELMEG AKKALSSGQD STAELGIEVI DVRVKQINLP
     DEVSSSIYQR MRAERDAVAR EHRSQGKEKA AFIQADVDRK VTLILANANK TAQELRGSGD
     AAAAKLYSDA FAQEPQFFTF VRSLKAYEAS FANSDNIMIL KPDSDFFRFM QAPKK