ID   HFLC_VIBCH              Reviewed;         326 AA.
AC   Q9KV08;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Protein HflC;
GN   Name=hflC; OrderedLocusNames=VC_0350;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: HflC and HflK could regulate a protease. {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE003852; AAF93523.1; -; Genomic_DNA.
DR   PIR; F82334; F82334.
DR   RefSeq; NP_230004.1; NC_002505.1.
DR   RefSeq; WP_001228766.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KV08; -.
DR   STRING; 243277.VC_0350; -.
DR   MEROPS; I87.001; -.
DR   DNASU; 2615063; -.
DR   EnsemblBacteria; AAF93523; AAF93523; VC_0350.
DR   GeneID; 57739087; -.
DR   KEGG; vch:VC_0350; -.
DR   PATRIC; fig|243277.26.peg.327; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_059167_3_0_6; -.
DR   OMA; DFFAFYR; -.
DR   BioCyc; VCHO:VC0350-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052547; P:regulation of peptidase activity; IEA:InterPro.
DR   CDD; cd03405; SPFH_HflC; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010200; HflC.
DR   PANTHER; PTHR42911; PTHR42911; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PIRSF; PIRSF005651; HflC; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01932; hflC; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Protein HflC"
FT                   /id="PRO_0000094079"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  36929 MW;  608E5644C217B384 CRC64;
     MRKLLIPSIV LIIAALLMSM FVIPEGERGI VIRFGRVLKD NNDLARIYEP GLHFKMPLFD
     RVKTLDARIQ TMDGRSDRFV TSEKKDVIID TYVKWRIEDF GQYYLATGGG NALTAEALLE
     RKVTDVLRSE IGAREIKQIV SGPRNVAVLP ENADSSELTT EAAKEAMEID GQRDQIMSEV
     LNDTRESAMK DLGVYVVDFR MKKINLPDEI SESIYRRMRA ERESVARKHR SQGREKAEVI
     RAQAELEVAT ILAEADKTAR VTRGTADAEA AKIYSDAYKK DPEFFSFLRS LRAYEKSFNS
     KNDILVLDPN SEFFQYMNNA KGAAAK