ID   HFLC_VIBPA              Reviewed;         326 AA.
AC   P40606;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Protein HflC;
GN   Name=hflC; OrderedLocusNames=VP2814;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB22;
RA   McCarter L.L.;
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: HflC and HflK could regulate a protease. {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U09005; AAA62187.1; -; Genomic_DNA.
DR   EMBL; BA000031; BAC61077.1; -; Genomic_DNA.
DR   RefSeq; NP_799193.1; NC_004603.1.
DR   RefSeq; WP_005460668.1; NC_004603.1.
DR   AlphaFoldDB; P40606; -.
DR   SMR; P40606; -.
DR   STRING; 223926.28807824; -.
DR   MEROPS; I87.001; -.
DR   PRIDE; P40606; -.
DR   EnsemblBacteria; BAC61077; BAC61077; BAC61077.
DR   GeneID; 1190364; -.
DR   KEGG; vpa:VP2814; -.
DR   PATRIC; fig|223926.6.peg.2705; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_059167_3_0_6; -.
DR   OMA; DFFAFYR; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0052547; P:regulation of peptidase activity; IEA:InterPro.
DR   CDD; cd03405; SPFH_HflC; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010200; HflC.
DR   PANTHER; PTHR42911; PTHR42911; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   PIRSF; PIRSF005651; HflC; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01932; hflC; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Protein HflC"
FT                   /id="PRO_0000094080"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  37135 MW;  9E14FC5CE77F1802 CRC64;
     MRKLMIPVLV IALALMLMSL FVIPEGERGI VVRFGRVLKD NNDITRIYEP GLHFKMPLFD
     RVKQLDARIQ TMDGRADRFV TSEKKDVIID SYVKWRIEDF GRYYLATGGG NSLTAEALLE
     RKVTDVLRSE IGAREIKQIV SGPRNDDVLP EDASSDEVNT EAAREALEID GERDLIMSDV
     LRDTRESAMK DLGVRVVDFR MKKINLPDEI SESIYRRMRA ERESVARKHR SQGREKAEII
     RAQAELEVAT ILAEADKTAR VTRGEADAEA AKIYANAYNK DPEFFSFLRS LRAYEKSFSS
     KNDILVLDPK SDFFQYMNNA KGAKAE