ID   HFLD_ECO57              Reviewed;         213 AA.
AC   Q8X736;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=High frequency lysogenization protein HflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN   Name=hflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN   OrderedLocusNames=Z1861, ECs1604;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Negative regulator of phage lambda lysogenization.
CC       Contributes to the degradation of the phage regulatory protein CII.
CC       Acts probably by holding CII on the membrane surface, away from the
CC       target promoters, but close to the FtsH protease. {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
CC   -!- SUBUNIT: Interacts with CII protein from phage lambda.
CC       {ECO:0000255|HAMAP-Rule:MF_00695}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane
CC       {ECO:0000255|HAMAP-Rule:MF_00695}; Peripheral membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_00695}; Cytoplasmic side {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
CC   -!- SIMILARITY: Belongs to the HflD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
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DR   EMBL; AE005174; AAG55958.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB35027.1; -; Genomic_DNA.
DR   PIR; B85687; B85687.
DR   PIR; D90829; D90829.
DR   RefSeq; NP_309631.1; NC_002695.1.
DR   RefSeq; WP_001301618.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X736; -.
DR   SMR; Q8X736; -.
DR   STRING; 155864.EDL933_1801; -.
DR   EnsemblBacteria; AAG55958; AAG55958; Z1861.
DR   EnsemblBacteria; BAB35027; BAB35027; ECs_1604.
DR   GeneID; 913287; -.
DR   KEGG; ece:Z1861; -.
DR   KEGG; ecs:ECs_1604; -.
DR   PATRIC; fig|386585.9.peg.1704; -.
DR   eggNOG; COG2915; Bacteria.
DR   HOGENOM; CLU_098920_0_0_6; -.
DR   OMA; RYIISLM; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.3890.10; -; 1.
DR   HAMAP; MF_00695; HflD_protein; 1.
DR   InterPro; IPR007451; HflD.
DR   InterPro; IPR035932; HflD-like_sf.
DR   PANTHER; PTHR38100; PTHR38100; 1.
DR   Pfam; PF04356; DUF489; 1.
DR   SUPFAM; SSF101322; SSF101322; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Coiled coil; Cytoplasm; Membrane;
KW   Reference proteome.
FT   CHAIN           1..213
FT                   /note="High frequency lysogenization protein HflD"
FT                   /id="PRO_0000071578"
FT   COILED          99..126
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00695"
SQ   SEQUENCE   213 AA;  22947 MW;  E26EF9678C3844E2 CRC64;
     MAKNYYDITL ALAGICQSAR LVQQLAHQGH CDADALHVSL NSIIDMNPSS TLAVFGGSEA
     NLRVGLETLL GVLNASSRQG LNAELTRYTL SLMVLKRKLS SAKGALDTLG NRINGLQRQL
     EHFDLQSETL MSAMAAIYVD VISPLGPRIQ VTGSPAVLQS PQVQAKVRAT LLAGIRAAVL
     WHQVGGGRLQ LMFSRNRLTT QAKQILAHLT PEL